Sofosbuvir Impurity B, also known as Chloro Sofosbuvir, is an impurity found in Sofosbuvir (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate. It is a nucleotide inhibitor of the hepatitis C virus, specifically targeting the HCV NS5B polymerase and exerting selective inhibitory effects.
1496552-51-2
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Basic information
- Product Name: Sofosbuvir IMpurity B
- Synonyms: Sofosbuvir IMpurity B;(S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate;Sofosbuvir impurity K;(2S)-isopropyl 2-(((((2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
- CAS NO:1496552-51-2
- Molecular Formula: C22H29ClN3O9P
- Molecular Weight: 545.907121
- EINECS: -0
- Product Categories: N/A
- Mol File: 1496552-51-2.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: 1.43±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 9.39±0.10(Predicted)
- CAS DataBase Reference: Sofosbuvir IMpurity B(CAS DataBase Reference)
- NIST Chemistry Reference: Sofosbuvir IMpurity B(1496552-51-2)
- EPA Substance Registry System: Sofosbuvir IMpurity B(1496552-51-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1496552-51-2(Hazardous Substances Data)
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1496552-51-2 Usage
Uses
Used in Pharmaceutical Industry:Sofosbuvir Impurity B is used as a reference material for the development and quality control of Sofosbuvir, an antiviral drug for the treatment of hepatitis C. It helps in ensuring the purity and efficacy of the drug by providing a benchmark for comparison during the manufacturing process.
Used in Research and Development:
Sofosbuvir Impurity B is used as a research tool in the study of the mechanism of action, pharmacokinetics, and pharmacodynamics of Sofosbuvir. It aids in understanding the drug's interaction with the hepatitis C virus and its potential side effects, which is crucial for the ongoing development and improvement of antiviral therapies.
Used in Quality Control and Regulatory Compliance:
Sofosbuvir Impurity B is used as a reference standard in the quality control and regulatory compliance of Sofosbuvir. It helps in the assessment of the drug's quality, safety, and efficacy, ensuring that it meets the required standards for approval and use in the treatment of hepatitis C.
Used in Drug Development and Formulation:
Sofosbuvir Impurity B is used in the development of new drug formulations and delivery systems for Sofosbuvir. It helps in the optimization of drug release, bioavailability, and overall therapeutic performance, leading to the development of more effective and safer antiviral treatments for hepatitis C.
Check Digit Verification of cas no
The CAS Registry Mumber 1496552-51-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,9,6,5,5 and 2 respectively; the second part has 2 digits, 5 and 1 respectively.Calculate Digit Verification of CAS Registry Number 1496552-51:
(9*1)+(8*4)+(7*9)+(6*6)+(5*5)+(4*5)+(3*2)+(2*5)+(1*1)=202
202 % 10 = 2
So 1496552-51-2 is a valid CAS Registry Number.
1496552-51-2Upstream product
1496552-51-2Downstream Products
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Sofosbuvir IMpurity B
