1496552-51-2

Basic information

• Product Name: Sofosbuvir IMpurity B
• Synonyms: Sofosbuvir IMpurity B;(S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate;Sofosbuvir impurity K;(2S)-isopropyl 2-(((((2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
• CAS NO: 1496552-51-2
• Molecular Formula: C22H29ClN3O9P
• Molecular Weight: 545.907121
• EINECS: -0
• Mol File: 1496552-51-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• PKA: 9.39±0.10(Predicted)
• CAS DataBase Reference: Sofosbuvir IMpurity B(CAS DataBase Reference)
• NIST Chemistry Reference: Sofosbuvir IMpurity B(1496552-51-2)
• EPA Substance Registry System: Sofosbuvir IMpurity B(1496552-51-2)

Safety Data

• Hazardous Substances Data: 1496552-51-2(Hazardous Substances Data)

Usage

Uses

Chloro Sofosbuvir is an impurity of Sofosbuvir (P839640); a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled Sofosbuvir as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.