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5-Bromo-3-(4-piperidinyl)-1H-indole, also known as Bromo-MPPP, is a synthetic designer drug belonging to the indole class of psychoactive substances. It is a derivative of the synthetic cathinone stimulant MPPP and is structurally related to other designer drugs such as MDPV and alpha-PVP. Bromo-MPPP acts as a potent and selective dopamine-norepinephrine reuptake inhibitor, increasing the levels of these neurotransmitters in the brain, which can lead to stimulant and euphoric effects. However, it also carries potential risks such as anxiety, paranoia, and cardiovascular problems. The drug is not approved for medical use and is primarily sold through illicit channels, often marketed as a "research chemical" or "legal high." Due to its psychoactive properties and potential for abuse, Bromo-MPPP has been classified as a controlled substance in various jurisdictions.

149669-42-1

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149669-42-1 Usage

Uses

Used in Research Applications:
5-Bromo-3-(4-piperidinyl)-1H-indole is used as a research chemical for studying the effects of dopamine-norepinephrine reuptake inhibition on the brain and its potential implications in the development of new treatments for neurological and psychiatric disorders.
Used in Illicit Drug Market:
Despite its classification as a controlled substance, 5-Bromo-3-(4-piperidinyl)-1H-indole is used as a "legal high" or "research chemical" in the illicit drug market, where it is sought after for its stimulant and euphoric effects. However, its use in this context poses significant health risks due to the potential for anxiety, paranoia, and cardiovascular problems.

Check Digit Verification of cas no

The CAS Registry Mumber 149669-42-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,6,6 and 9 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 149669-42:
(8*1)+(7*4)+(6*9)+(5*6)+(4*6)+(3*9)+(2*4)+(1*2)=181
181 % 10 = 1
So 149669-42-1 is a valid CAS Registry Number.

149669-42-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-bromo-3-piperidin-4-yl-1H-indole

1.2 Other means of identification

Product number -
Other names 5-bromo-3-[piperidine-4-yl]-1H-indole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:149669-42-1 SDS

149669-42-1Downstream Products

149669-42-1Relevant academic research and scientific papers

Synthesis and structure-activity relationships of novel histamine H 1 antagonists: Indolylpiperidinyl benzoic acid derivatives

Fonquerna, Silvia,Miralpeix, Montse,Pagès, Lluís,Puig, Carles,Cardús, Arantxa,Antón, Francisca,Cárdenas, álvaro,Vilella, Dolors,Aparici, Mónica,Calaf, Elena,Prieto, José,Gras, Jordi,Huerta, Josep M.,Warrellow, Graham,Beleta, Jorge,Ryder, Hamish

, p. 6326 - 6337 (2007/10/03)

A series of indolylpiperidinyl derivatives were prepared and evaluated for their activity as histamine H1 antagonists. Structure-activity relationship studies were directed toward improving in vivo activity and pharmacokinetic profile of our first lead (1). Substitution of fluorine in position 6 on the indolyl ring led to higher in vivo activity in the inhibition of histamine-induced cutaneous vascular permeability assay but lower selectivity toward 5HT2 receptor. Extensive optimization was carried out within this series and a number of histamine H1 antagonists showing potency and long duration of action in vivo and low brain penetration or cardiotoxic potential were identified. Within this novel series, indolylpiperidines 15, 20, 48, 51 and 52 exhibited a long half-life in rat and have been selected for further preclinical evaluation.

Morpholinyl tachykinin receptor antagonists

-

, (2008/06/13)

This invention provides methods of treating a physiological disorder associated with an excess of tachykinins in a mammal which comprises administering to a mammal in need of said treatment a compound selected from a series of substituted morpholines. Thi

Bisindoles as tachykinin receptor antagonists

-

, (2008/06/13)

This invention provides a series of substituted bisindole propanamides which are useful as tachykinin receptor antagonists and as serotonin agonists. This invention also provides methods for the treatment of related disorders as well as pharmaceutical for

5-HT1F agonists for the treatment of migraine

-

, (2008/06/13)

This invention provides novel 5-HT1F agonists which are useful for the treatment of migraine and associated disorders.

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