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(2R)-2-(2,6-difluorophenyl)propionitrile, commonly known as flufenamic acid, is a nonsteroidal anti-inflammatory drug (NSAID) characterized by its potent inhibition of prostaglandin synthesis. This chemical compound is distinguished by its chiral center, with the R-configuration at the 2-position, and features a 2,6-difluorophenyl group attached to a propionitrile moiety. Flufenamic acid exerts its therapeutic effects by blocking the cyclooxygenase enzyme, thereby reducing inflammation, pain, and fever.

149680-18-2

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149680-18-2 Usage

Uses

Used in Pharmaceutical Industry:
Flufenamic acid is utilized as an anti-inflammatory agent for the treatment of conditions characterized by pain, fever, and inflammation. Its mechanism of action involves the inhibition of cyclooxygenase, which is crucial for prostaglandin synthesis, thus providing relief from the symptoms associated with inflammation.
Used in Pain Management:
In the field of pain management, flufenamic acid serves as an analgesic, helping to alleviate pain by reducing the levels of prostaglandins that are responsible for pain perception and inflammation.
Used in Research:
Flufenamic acid is also used in research settings to study the role of prostaglandins and cyclooxygenase enzymes in various physiological and pathological processes. Its ability to inhibit these targets makes it a valuable tool in understanding the underlying mechanisms of inflammation and pain.
Used in Anticancer Research:
The potential anticancer properties of flufenamic acid are being investigated in the field of oncology. Its effects on prostaglandin synthesis and other cellular pathways may offer new avenues for cancer treatment and prevention.
Used in Neurodegenerative Disease Research:
Flufenamic acid is being studied for its potential as a treatment for neurodegenerative diseases. Its ability to modulate inflammatory pathways and potentially impact cellular processes involved in neurodegeneration makes it a candidate for further exploration in this area.

Check Digit Verification of cas no

The CAS Registry Mumber 149680-18-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,6,8 and 0 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 149680-18:
(8*1)+(7*4)+(6*9)+(5*6)+(4*8)+(3*0)+(2*1)+(1*8)=162
162 % 10 = 2
So 149680-18-2 is a valid CAS Registry Number.

149680-18-2Upstream product

149680-18-2Downstream Products

149680-18-2Relevant academic research and scientific papers

Stereoselective synthesis of 2-substituted 6-[1-(2,6-difluorophenyl)ethyl]- 5-methylpyrimidin-4(3H)-ones

Mai,Artico,Rotili,Novakov,Orlinson,Navrotskii,Eremiichuk,Gordeeva

experimental part, p. 1531 - 1534 (2010/03/30)

A procedure has been proposed for the synthesis of 2-(cyclopentylsulfanyl)- 6-[(1R)-1-(2,6-difluorophenyl) ethyl]-5-methylpyrimidin-4(3H)-one through intermediate (3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl (2R)-2-(2,6- difluorophenyl)propanoate which was

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