149695-61-4Relevant academic research and scientific papers
New series of aryloxypropanolamines with both human β3-adrenoceptor agonistic activity and free radical scavenging properties
Aubriot, Silvere,Nicolle, Edwige,Lattier, Mireille,Morel, Cecile,Cao, Wenhong,Daniel, Kiefer W.,Collins, Sheila,Leclerc, Gerard,Faure, Patrice
, p. 209 - 212 (2007/10/03)
A series of 13 novel hybrid molecules designed to possess both free radical scavenging activity and to stimulate the β3-adrenoceptors in order to improve antidiabetic effect and to restore insulin sensitivity was synthesized and evaluated. Compounds were of quinolyl-, isoquinolyl-, pyridoindolyl- or carbazolyloxypropanolamine structure with a terminal amino group of benzopyranolyl-, di-tert-butylphenolyl- or methoxyindolyl-type. Some of the products possessed both the expected activities.
Process for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4-aminophenoxymethyl) chromans
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, (2008/06/13)
A novel process for the preparation of aminochromans of the general formula: STR1 wherein R is a lower alkyl group having 1 to 4 carbon atoms. In the process, nitrochromanones of the general formula: STR2 are reduced using zirconium oxide/isopropanol to g
Method for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4-aminophenoxymethyl) chromans
-
, (2008/06/13)
A novel process for the preparation of aminochromans of the general formula: STR1 wherein R is a C1 -C4 alkyl group. In the process, a nitrochromanone of the general formula: STR2 is hydrogenated with hydrogen in the presence of a hydrogenation catalyst. The resultant aminochromanone (III) is reduced using zirconium oxide/isopropanol to the aminochromene (IV). The latter is finally hydrogenated with hydrogen in the presence of a hydrogenation catalyst to give the final product. The aminochromans are useful intermediates for the preparation of hypolipidaemic pharmaceuticals.
