149704-10-9

Upstream product

• 19228-91-2 tert-butyl 3-thienylcarbamate 

Downstream Products

• 851199-00-3 (tert-butoxy)-N-[2-(4-bromophenyl)(3-thiophenyl)]carboxamide 

Relevant academic research and scientific papers

THIENYLPYRIDYLCARBOXAMIDES

Novel thienylpyridylcarboxamides of the formula (I) The present application is also directed to a plurality of processes for preparing these compounds and their use for controlling unwanted microorganisms, and also novel intermediates and their preparatio

AMPA RECEPTOR POTENTIATORS

The present invention relates to AMPA receptor potentiators of Formula I: formulations comprising them, methods for their use, and intermediates useful for their preparation.

PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS

The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.

SILYLATED CARBOXAMIDES

The invention relates to novel silylated carboxamides of formula (I), where M, L, R1, R2, R3, R and A have the meanings given in the description, several methods for production of said materials, the use thereof for the prevention of undesired microorganisms, novel intermediates and the production thereof.

α-Substitution of β-thienylcarbamates: Alkylation, vinylation and Pd- catalyzed coupling reactions

Reaction of the trilithio derivative of di-t-butyl thiophene-3,4- diyldicarbamate 4 with alkyl halides has led to 2-alkylthiophenedicarbamates 9 and 11 and 4-alkylthieno[3,4-d]imidazolones 12. Acid catalyzed α- alkylation of 4, using α-branched or functionalized aldehydes, has allowed the synthesis of divinylthiophenes 13 and thieno[3,2-b]pyridines 14-16, respectively. Pd-catalyzed coupling reactions involving halo- or dihalothienylcarbamates 10, 17, 18 were studied. One or two alkenyl, alkynyl, aryl groups were introduced on the thiophene nucleus. (C) 2000 Elsevier Science Ltd.

Indole-3-acetic acids and hetero analogues by one pot synthesis including Heck cyclisation

Bz-substituted indole-3-acetic acid ethyl esters (14e-g) and heteroanalogues, i.e. thienopyrroles (14a,c) and selenolopyrrole (14d), were prepared starting from N-BOC protected o-iodo aryl amines. Allylation with ethyl 4-bromocrotonate, followed by palladium-catalysed ring closure in a one pot reaction, yielded N-BOC protected indoles (13e-g), thienopyrroles (13a-c), and selenolopyrrole (13d). The BOC group was readily removed thermally after adsorption on silica. Oxothienopyrroles (11a-c) were similarly prepared.

Palladium-Catalysed Synthesis of Heterocondensed Pyrroles

The palladium-catalysed preparation of some heterocondensed pyrroles from ortho nitrogen containing hetaryl iodides and derivatives of propargyl alcohol is described.