149740-25-0Relevant academic research and scientific papers
MTA-Cooperative PRMT5 Inhibitors
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Paragraph 0319, (2021/03/19)
The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.
Mild palladium-catalyzed regioselective direct arylation of azoles promoted by tetrabutylammonium acetate
Bellina, Fabio,Lessi, Marco,Manzini, Chiara
, p. 5621 - 5630 (2013/09/12)
A mild, general, and convenient palladium-catalyzed direct arylation of the 5-position of azoles with aryl bromides, efficiently promoted by tetrabutylammonium acetate, is described. 1-Methylpyrazole, oxazole, and thiazole reacted at 70°C in N,N-dimethyla
