1497410-67-9Relevant academic research and scientific papers
Organocatalyzed stereospecific C-C bond formation of β-lactams
Pawar, Sachin A.,Alapour, Saba,Khanyase, Sibusiso,Cele, Zamani E. D.,Chitti, Srinivas,Kruger, Hendrik G.,Govender, Thavendran,Arvidsson, Per I.
, p. 8294 - 8297 (2013)
Herein, we report the development of mild, organocatalyzed routes to novel carbapenam derivatives through aldol, Mannich and Michael C-C bond forming reactions.
L-Proline organocatalyzed Michael synthesis of monobactam and carbapenem β-lactam cores
Khanyase, Sibusiso,Naicker, Tricia,Maguire, Glenn E.M.,Kruger, Hendrik G.,Arvidsson, Per I.,Govender, Thavendran
, p. 969 - 973 (2014/08/18)
Herein, we report the development of mild, organocatalyzed routes to novel β-lactam carbapenem derivatives through Michael type CC bond forming reactions. The same methodology, followed by a retro-Dieckmann reaction, provides a pathway to novel and highly functionalized monobactam derivatives, another class of valuable β-lactam antibiotics.
