149771-16-4 Usage
General Description
2-(Methylthio)-4,5-pyrimidinedicarboxylic acid, also known as thiamine disulfide, is a chemical compound with the molecular formula C9H8N2O4S2. It is a derivative of pyrimidine and is often used as a pharmaceutical intermediate in the synthesis of drugs and research chemicals. 2-(Methylthio)-4,5-pyrimidinedicarboxylic Acid has been studied for its potential role in treating neurological disorders and has been found to have antioxidant and neuroprotective properties. Additionally, it has been shown to have potential applications in the treatment of cancer and other diseases. Overall, 2-(Methylthio)-4,5-pyrimidinedicarboxylic acid is a versatile compound with potential therapeutic benefits in various medical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 149771-16-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,7,7 and 1 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 149771-16:
(8*1)+(7*4)+(6*9)+(5*7)+(4*7)+(3*1)+(2*1)+(1*6)=164
164 % 10 = 4
So 149771-16-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H6N2O4S/c1-14-7-8-2-3(5(10)11)4(9-7)6(12)13/h2H,1H3,(H,10,11)(H,12,13)
149771-16-4Relevant articles and documents
Synthesis and structure-activity relationship studies of conformationally restricted, analogs of 2-chloro-4-trifluoromethylpyrimidine- 5-[N-(3',5'-bis(trifluoromethyl)phenyl)]carboxamide
Palanki, Moorthy S.S.,Erdman, Paul E.,Goldman, Mark E.,Suto, Carla,Suto, Mark J.
, p. 19 - 29 (2007/10/03)
2-Chloro-4-trifluoromethylpyrimidine-5-N[(3,5- bis(trifluoromethyl)phenyl] carboxamide (1) was identified as an inhibitor of AP-1 and NF-κB mediated transcriptional activation. In an effort to identify novel compounds that contain less number of trifluoromethyl groups with comparable potency as 1, several conformationally restricted analogs of I were synthesized in which the pyrimidine ring and the aniline ring were connected through a second 'bridge'. The 7-membered sulfur bridged analog was the most potent in this series, and comparable to 1 in activity.
