149813-41-2

Upstream product

• 149813-39-8 (2S,4R)-N-t-butoxycarbonyl-4-t-butyldimethylsilyloxy-2-[1-hydroxy-3-(p-toluenesulfonyloxy)propyl]pyrrolidine 
• 149814-65-3 (2S,4R)-N-t-butoxycarbonyl-4-t-butyldimethylsilyloxy-2-(2-ethoxycarbonyl-1-hydroxyethyl)pyrrolidine 
• 149813-00-3 (3R,5S)-N-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxy-5-((R)-1,3-dihydroxypropyl)pyrrolidine 
• 134441-71-7 (2S,4R)-1-boc-4-tert-butyldimethylsilylpyrrolidine-2-carbaldehyde 
• 4457-32-3 4-nitrobenzyl chloroformate 

Downstream Products

• 1054624-22-4 (2S,4S)-2-{(R)-1-Hydroxy-3-[methyl-(4-nitro-benzyloxycarbonyl)-amino]-propyl}-4-mercapto-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester 
• 149813-43-4 (2S,4S)-4-acetylthio-2-{1-hydroxy-3-[N-(p-nitrobenzyloxycarbonyl)-N-methylamino]propyl}-N-(p-nitrobenzyloxycarbonyl)pyrrolidine 

Relevant academic research and scientific papers

1β-methyl-2-(5-substituted pyrrolidin-3-ylthio)carbapenems; 3. Synthesis and antibacterial activity of BO-2727 and its related compounds

The synthesis and biological activity of (1R,5S,6S)-2-[(3S,5S)-5-substituted pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3 -carboxylic acid in which hydroxy-substituted aminoethyl, aminopropyl, and aminobutyl groups were introduced as substituents, are described. These derivatives showed potent antibacterial activity against Gram-positive and Gram-negative bacteria including P. aeruginosa. Among them, lenapenem (BO-2727, 7b), carrying an (R)-1-hydroxy-3-(N-methylamino)propyl group, was selected as a development candidate.