1498335-02-6

Basic information

• Product Name: 4-(4-(cyanomethyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide
• Synonyms: 4-(4-(cyanomethyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide
• CAS NO: 1498335-02-6
• Molecular Weight: 292.318
• Mol File: 1498335-02-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-(cyanomethyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-(cyanomethyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide(1498335-02-6)
• EPA Substance Registry System: 4-(4-(cyanomethyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide(1498335-02-6)

Safety Data

• Hazardous Substances Data: 1498335-02-6(Hazardous Substances Data)

Upstream product

• 1498334-98-7 4-(4-((dimethylamino)methyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide 
• 17852-52-7 4-hydrazinobenzene-1-sulfonamide hydrochloride 
• 13269-73-3 4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide 

Downstream Products

• 1498335-05-9 2-(3-methyl-5-oxo-1-(4-sulfamoylphenyl)-4,5-dihydro-1H-pyrazol-4-yl)acetic acid 
• 1498335-08-2 methyl 2-(3-methyl-5-oxo-1-(4-sulfamoylphenyl)-4,5-dihydro-1H-pyrazol-4-yl)acetate 

Relevant articles and documents

Pyrazolone derivatives: Synthesis, anti-inflammatory, analgesic quantitative structure-activity relationship and in vitro studies

Some 1-(4-chlorophenyl or benzenesulfonamide)-2,3- and/or 4-substituted-1H-pyrazol-5(4H)-one derivatives were synthesized and screened for their anti-inflammatory and analgesic activities, in addition to their ulcerogenic liability. They were found to be active as anti-inflammatory and analgesic agents. Compound 6b was found to be the most active as anti-inflammatory agent and compound 9b was found to be the most active one as anti-inflammatory and analgesic agent. On the other hand, cyclooxygenase-1/-2 (COX-1)/COX-2 isozyme selectivity was also done and the tested compounds showed equal inhibition to both isoforms. Moreover, 2D-quantitative structure-activity relationship (QSAR) studies revealed well predictive and statistically significant and cross validated QSAR model that helps to explore some expectedly potent compounds.