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14984-43-1

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14984-43-1 Usage

Purpose

Hormone replacement therapy in postmenopausal women

Symptoms Alleviated

Hot flashes
Vaginal dryness
Osteoporosis

Tissue-Specific Effects

Acts as estrogen in some tissues
Acts as progestogen in others
Has androgenic effects

Beneficial Effects

Maintains bone density
Prevents fractures in postmenopausal women
Improves sexual function
Enhances overall quality of life

Associated Risks

Increased risk of stroke
Increased risk of venous thromboembolism
Increased risk of breast cancer

Recommendation

Use should be carefully considered in consultation with a healthcare provider

Check Digit Verification of cas no

The CAS Registry Mumber 14984-43-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,9,8 and 4 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 14984-43:
(7*1)+(6*4)+(5*9)+(4*8)+(3*4)+(2*4)+(1*3)=131
131 % 10 = 1
So 14984-43-1 is a valid CAS Registry Number.

14984-43-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-amino-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one

1.2 Other means of identification

Product number -
Other names 2-Aminoestron

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14984-43-1 SDS

14984-43-1Relevant articles and documents

NOVEL AND REGIOSPECIFIC SYNTHESIS OF 2-AMINO ESTROGENS VIA ZINCKE NITRATION

Numazawa, Mitsuteru,Kimura, Katsuhiko

, p. 675 - 682 (1983)

An efficient synthesis of 2-aminoestrone (14), 2-aminoestradiol (15), 2-amino-16α-hydroxyestrone (16) and 2-aminoestriol (17) is described. 2,4-Dibromo estrogens 1 - 4 were regiospecifically converted to the corresponding 2-nitro-4-bromo derivatives 5 - 8 in quantitative yields, with Zincke nitration using sodium nitrite.Catalytic hydrogenation of the 2-nitro-4-bromides 5 - 8 over palladium-on-charcoal gave directly the desired 2-amino estrogens 14 - 17 in high yields.The 2-amino compounds 15 and 17 were also obtained by the reduction of the corresponding 2-nitro-4-bromides 6 and 8 with sodium borohydride in the presence of palladium chloride.

COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATMENT OF ANDROGEN-MEDIATED DISEASE

-

, (2020/05/28)

Provided herein are steroid sulfatase inhibitor compounds and androgen receptor inhibitor compounds that can be useful in, for example, the treatment of cancers such as prostate cancer and breast cancer. Pharmaceutical compositions and kits including the

Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors

Lawrence Woo,Leblond, Bertrand,Purohit, Atul,Potter, Barry V.L.

, p. 2506 - 2519 (2012/06/01)

Estrone sulfamate (EMATE) is a potent irreversible inhibitor of steroid sulfatase (STS). In order to further expand SAR, the compound was substituted at the 2- and/or 4-positions and its 17-carbonyl group was also removed. The following general order of p

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