14984-68-0

Basic information

• Product Name: Cloperastine hydrochloride
• Synonyms: 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidinhydrochloride;1-(2-(p-cloro-alpha-fenilbenzilossi)etil)piperidinacloridrato;2-piperidinoethylp-chlorobenzhydryletherhydrochloride;cloperastinacloridrato;ht11;hustazol;4-CHLOROBENZHYDRYL 2-[1-PIPERIDYL]-ETHYL ETHER HYDROCHLORIDE;1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]piperidinium chloride
• CAS NO: 14984-68-0
• Molecular Formula: C₂₀H₂₄ClNO*ClH
• Molecular Weight: 366.32
• EINECS: 239-067-8
• Mol File: 14984-68-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 147.9°
• Boiling Point: 423.9 °C at 760 mmHg
• Flash Point: 210.2 °C
• Appearance: /
• Vapor Pressure: 2.15E-07mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Merck: 14,2395
• CAS DataBase Reference: Cloperastine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Cloperastine hydrochloride(14984-68-0)
• EPA Substance Registry System: Cloperastine hydrochloride(14984-68-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36
• WGK Germany: 3
• RTECS: TM6491500
• Hazardous Substances Data: 14984-68-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 14984-68-0 differently. You can refer to the following data:
1. Antitussive;'Histamine antagonist
2. Cloperastine Hydrochloride is an anti-tussive drug as an over-the-counter cold medicine.

InChI:InChI=1/C20H24ClNO.ClH/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22;/h1,3-4,7-12,20H,2,5-6,13-16H2;1H

Synthetic route

Cloperastine hydrochloride (14984-68-0) → 1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]piperidinone

Conditions	Yield
With water; oxygen; sodium hydroxide In tetrahydrofuran at 60℃; under 760.051 Torr; for 24h; Green chemistry; regioselective reaction;	93%

Upstream product

• 1932-03-2 2-(piperidin-4-yl)ethyl chloride 
• 119-56-2 (4-chlorophenyl)phenylmethanol 
• 3040-44-6 1-piperidinoethanol 
• 134-83-8 1-chloro-4-(chloro(phenyl)methyl)benzene 

Related news

Effects of solid-state reaction between paracetamol and Cloperastine hydrochloride (cas 14984-68-0) on the pharmaceutical properties of their preparations07/16/2019

Tablets containing both paracetamol (PM) and cloperastine hydrochloride (CLH) in a combination formulation prepared by standard vertical granulation technology were found to have altered pharmaceutical properties. The hardness and disintegration time of tablets containing both PM and CLH gradual...detailed

Relevant articles and documents

Preparation method of cloperadine hydrochloride

The invention relates to a preparation method of cloperadine hydrochloride, which comprises the following steps: placing a formula VI and a formula III in a solvent or without a solvent, carrying out condensation or etherification reaction, and separating to obtain 1-[2-[(4-chloro-alpha phenyl benzyl) oxygen] ethyl] piperidine (II); and salifying the 1-[2-[(4-chloro-alpha phenyl benzyl) oxygen] ethyl] piperidine with hydrogen chloride or hydrochloric acid in a solvent to obtain the cloperadine hydrochloride. The method is mild in process condition, convenient and simple to operate and suitable for large-scale industrial production, the purity of the produced target product reaches 99.7% or above, and the single impurity is smaller than 0.1%.