149847-13-2Relevant academic research and scientific papers
The role of imine-enamine tautomerism in effecting cross-aldol condensations
Babler, James H.,Atwood, Matthew C.,Freaney, Jonathan E.,Viszlay, Anthony R.
, p. 7665 - 7667 (2007)
An indirect method to effect cross-aldol coupling of two nonequivalent enolizable aldehydes is reported that involves initial conversion of one aldehyde to an imine derivative possessing an N-3° alkyl substituent. In sharp contrast to the related couplings (e.g., the use of α-lithiated imines at low temperature), condensation between the imine and several representative aldehydes occurs readily at ambient temperature in the presence of a catalytic amount of cobalt(II) chloride.
