14985-83-2

Basic information

• Product Name: 2,2-dichloro-N-(2-methylphenyl)acetamide
• Synonyms: 2,2-dichloro-N-(2-methylphenyl)acetamide;2,2-DICHLORO-N-O-TOLYL-ACETAMIDE
• CAS NO: 14985-83-2
• Molecular Formula: C₉H₉Cl₂NO
• Molecular Weight: 218.08
• Mol File: 14985-83-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 332.2°Cat760mmHg
• Flash Point: 154.7°C
• Appearance: /
• Density: 1.346g/cm³
• Vapor Pressure: 0.000148mmHg at 25°C
• Refractive Index: 1.594
• CAS DataBase Reference: 2,2-dichloro-N-(2-methylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dichloro-N-(2-methylphenyl)acetamide(14985-83-2)
• EPA Substance Registry System: 2,2-dichloro-N-(2-methylphenyl)acetamide(14985-83-2)

Safety Data

• Hazardous Substances Data: 14985-83-2(Hazardous Substances Data)

Usage

Physical form

White crystalline solid

Uses

Broad-spectrum antimicrobial agent in industrial and agricultural applications, used in paints, adhesives, water treatment chemicals, and synthesis of other organic compounds

Mechanism of action

Inhibits bacterial growth

Safety precautions

Classified as harmful if swallowed, inhaled, or in contact with skin and eyes, recommended to use appropriate protective equipment and follow safety guidelines when handling

InChI:InChI=1/C9H9Cl2NO/c1-6-4-2-3-5-7(6)12-9(13)8(10)11/h2-5,8H,1H3,(H,12,13)

Upstream product

• 79-43-6 dichloro-acetic acid 
• 95-53-4 o-toluidine 
• 60-29-7 diethyl ether 
• 141-82-2 malonic acid 
• 93-68-5 3-oxo-N-o-tolylbutanamide 
• 79-36-7 dichloroacethyl chloride 
• 535-15-9 ethyl 1,1-dichloroacetate 

Relevant articles and documents

Synthesis, structural, vibrational and quantum chemical investigations of N-(2-methylphenyl)-2,2-dichloroacetamide and N-(4-methylphenyl)-2,2-dichloroacetamide

N-(2-Methylphenyl)-2,2-dichloroacetamide (2MPA) and N-(4-methylphenyl)-2,2-dichloroacetamide (4MPA) of the configuration XyC6H5-y-NHCO-CHCl2 (where, X = CH3 and y = 1) were synthesised and an extensiv

Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships

Dichloroacetophenone is a pyruvate dehydrogenase kinase 1 (PDK1) inhibitor with suboptimal kinase selectivity. Herein, we report the synthesis and biological evaluation of a series of novel dichloroacetophenones. Structure-activity relationship analyses (SARs) enabled us to identify three potent compounds, namely 54, 55, and 64, which inhibited PDK1 function, activated pyruvate dehydrogenase complex, and reduced the proliferation of NCI-H1975 cells. Mitochondrial bioenergetics assay suggested that 54, 55, and 64 enhanced the oxidative phosphorylation in cancer cells, which might contribute to the observed anti-proliferation effects. Collectively, these results suggested that 54, 55, and 64 could be promising compounds for the development of potent PDK1 inhibitors.

Divergent synthesis of α,α-dihaloamides through α,α-dihalogenation of β-oxo amides by using N-halosuccinimides

An efficient and divergent one-pot synthesis of α,α- dihaloamides from readily available β-oxo amides based on the selection of reaction conditions is reported. α,α-Dihalo-β-oxo amides were produced by treating β-oxo amides with N-chlorosuccinimide (NCS) or N-bromosuccinimide (NBS) in water at room temperature, whereas α,α-dihaloacetamides were synthesized by subjecting β-oxo amides to NCS or NBS in ethanol under reflux. A divergent synthesis of α,α-dihalo-β-oxo amides and α,α-dihaloacetamides has been developed from readily available β-oxo amides. Upon treatment with N-halosuccinimides in water at room temperature, α,α-dihalo-β- oxo amides were produced, whereas dihaloacetamides were synthesized by treatment of β-oxo amides with N-halosuccinimides in ethanol under reflux. Copyright