149885-08-5

Upstream product

• 149836-98-6 (4S,5R)-3-{(2R,3S)-3-((R)-1-Benzyloxy-ethyl)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-trimethylsilanyl-pent-4-ynoyl}-4-methyl-5-phenyl-oxazolidin-2-one 
• 149885-07-4 (2R,3R)-2-((R)-1-Benzyloxy-ethyl)-3-tert-butoxycarbonylamino-5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid 
• 175656-29-8 {(1R,2R)-2-((R)-1-Benzyloxy-ethyl)-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-ynyl}-carbamic acid tert-butyl ester 
• 149837-00-3 (2R,3S)-3-((R)-1-Benzyloxy-ethyl)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pent-4-ynoic acid 
• 1027868-85-4 (2R,3R)-3-Amino-2-((R)-1-benzyloxy-ethyl)-5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid 

Relevant academic research and scientific papers

Formal total syntheses of the β-lactam antibiotics thienamycin and PS-5

Chiral nonracemic acetylenic acids of general structure 11, prepared using the Schreiber modification of the Nicholas reaction, have been converted to β-amino acid derivatives of type 12 by a two-step sequence involving Curtius rearrangement followed by o

A versatile synthesis of β-amino acids using the nicholas reaction. II. Formal total synthesis of thienamycin

Homochiral acetylenic acid 26, prepared using the Schreiber modification of the Nicholas reaction, has been converted to β-amino acid derivative 28 by a two step sequence involving Curtius rearrangement fallowed by oxidative clevage of the acetylenic bond