149897-41-6

Usage

Uses

Used in Pharmaceutical Research:
4-IodoMethyl-piperidine-1-carboxylic acid benzyl ester is used as a building block for the synthesis of various pharmaceutical compounds, contributing to the development of medications for the treatment of different medical conditions.
Used in Organic Synthesis:
In the chemical industry, 4-IodoMethyl-piperidine-1-carboxylic acid benzyl ester is utilized as an intermediate in organic synthesis processes, facilitating the creation of a range of chemical products.
Used in Medication Development:
4-IodoMethyl-piperidine-1-carboxylic acid benzyl ester is used as a precursor in the development of new medications, targeting a variety of medical conditions due to its unique structure and properties.
Used in Chemical and Pharmaceutical Industries:
4-IodoMethyl-piperidine-1-carboxylic acid benzyl ester is of significant interest in both the chemical and pharmaceutical industries, where it is employed for its potential applications in creating innovative products and therapeutic agents.

Upstream product

• 122860-33-7 benzyl 4-(hydroxymethyl)piperidine-N-carboxylate 
• 6457-49-4 4-piperidinemethanol 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 652130-42-2 1-benzyloxycarbonyl-4-[(5,6-dimethoxy-2-ethoxycarbonylindan-1-on-2-yl)methyl]piperidine 

Relevant academic research and scientific papers

Nickel-Catalyzed C-Alkylation of Nitroalkanes with Unactivated Alkyl Iodides

Enabled by nickel catalysis, a mild and general catalytic method for C-alkylation of nitroalkanes with unactivated alkyl iodides is described. Compatible with primary, secondary, and tertiary alkyl iodides; and tolerant of a wide range of functional groups, this method allows rapid access to diverse nitroalkanes.

METALLO-BETA-LACTAMASE INHIBITORS

The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS

The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

Process for the preparation of donepezil

The invention provides a process for the preparation of a compound of the formula 6 comprising the hydrolysis and decarboxylation of a compound of the formula 5 according to the reaction: wherein R and R2 independently a C1-C4 alkyl group or an aralkyl group.

Process for the preparation of Donepezil

The invention provides a process for the preparation of a compound of the formula 6 comprising the hydrolysis and decarboxylation of a compound of the formula 5 according to the reaction: wherein R and R2 are independently a C1-C4 alkyl group or an aralkyl group.

QUINOLINE DERIVATIVES AS ANTIBACTERIALS

A method of treatment of bacterial infections in mammals, particularly in man, which method comprises the administration to a mammal in need of such treatment of an effective amount of a quinoline of formula (I) or a pharmaceutically acceptable derivative thereof wherein: n is 0, 1 or 2; A is NR, O, S(O)x or CRR and B is NR, O, S(O)x or CRR where x is 0, 1 or 2 novel quinolines for use in the method.