1499076-41-3

Upstream product

• 35132-20-8 (R,R)-1,2-diphenylethylenediamine 
• 1499076-20-8 N,N'-((1R,2R)-1,2-diphenylethane-1,2-diyl)bis(2-chloroacetamide) 
• 1499076-22-0 (2R,3R)-2,3-diphenyl-1,4-diazabicyclo[2.2.2]octane 
• 1499076-27-5 (2R,3R)-1-methyl-2,3-diphenyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate 
• 1499076-38-8 N,N'-((1S,2S)-1,2-bis(4-(trifluoromethyl)phenyl)ethane-1,2-diyl)bis(2-chloroacetamide) 

Downstream Products

• 1499076-43-5 (2S,3S)-2,3-bis(4-(trifluoromethyl)phenyl)-1,4-diazabicyclo[2.2.2]octane 

Relevant academic research and scientific papers

CHIRAL FLUORINATING REAGENTS

This invention relates to fluorinating agents and, more particularly, to chiral non-racemic fluorinating agents useful for enantioselective fluorination, as well as to their synthesis and use and other subject matter. The fluorinating agents are based on a substituted 1,4-diazabicyclo[2.2.2]octane (DABCO) skeleton and provide electrophillic fluorine enantioselectively.

Asymmetric electrophilic fluorocyclization with carbon nucleophiles

Twist of 'F'ate: Various helical-shaped fluorinated tetracyclic molecules were prepared by fluorocarbocyclization of prochiral alkenes. The development of a new class of chiral Selectfluor (1) proved instrumental in developing an asymmetric variant of this transformation. These novel chiral N-F reagents are readily accessible by fluorine transfer from shelf-stable N-fluoropyridinium salts. Copyright