149915-83-3

Basic information

• Product Name: 2-Butanone, 1-methoxy-3-methyl-4-(phenylmethoxy)-, (3R)-
• CAS NO: 149915-83-3
• Molecular Formula: C13H18O3
• Molecular Weight: 222.284
• Mol File: 149915-83-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Butanone, 1-methoxy-3-methyl-4-(phenylmethoxy)-, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanone, 1-methoxy-3-methyl-4-(phenylmethoxy)-, (3R)-(149915-83-3)
• EPA Substance Registry System: 2-Butanone, 1-methoxy-3-methyl-4-(phenylmethoxy)-, (3R)-(149915-83-3)

Safety Data

• Hazardous Substances Data: 149915-83-3(Hazardous Substances Data)

Upstream product

• 14704-15-5 methoxymethyllithium 
• 116652-76-7 (2R)-3-benzyloxy-N-methoxy-N-methyl-2-methylpropanamide 

Downstream Products

• 149915-84-4 (E)-(2R,4R,5R,8R)-1-Benzyloxy-9-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-4-methoxy-2,6,8-trimethyl-non-6-en-3-one 

Relevant articles and documents

High ?-Face Selectivity in Anti Aldol Reactions of E-Enol Borinates from Chiral Alkoxymethyl Ketones: Stereocontrolled Synthesis of a C24-C32 Polyol Subunit of Rapamycin

Using (c-C6H11)2BCl/Et3N, the aldol reactions of the α-chiral alkoxymethyl ketones 5 and 6 with achiral aldehydes gives the 1,2-anti-2,4-anti adducts 7 and 8 in 83-95 percent yield with >/= 95 percent diastereoselectivity.This novel aldol reaction was applied to a concise and highly stereocontrolled synthesis of the C24-C32 subunit 9 of rapamycin (10).