149915-92-4

Upstream product

• 92817-88-4 (2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropanal 
• 176900-65-5 (2E,4S)-2,4-dimethyl-5-(tert-butyldiphenylsilyloxy)-2-pentanoic acid methyl ester 
• 934558-74-4 (E)-(R)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pent-2-en-1-ol 

Downstream Products

• 149915-84-4 (E)-(2R,4R,5R,8R)-1-Benzyloxy-9-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-4-methoxy-2,6,8-trimethyl-non-6-en-3-one 
• 943897-91-4 C₃₈H₅₀O₆Si 
• 1527498-77-6 (4S,7R,E)-8-(((tert-butyl)diphenylsilyl)oxy)-5,7-dimethylocta-1,5-dien-4-ol 
• 1527498-78-7 (4R,7R,E)-8-(((tert-butyl)diphenylsilyl)oxy)-5,7-dimethylocta-1,5-dien-4-ol 
• 346708-22-3 (E)-(2R,4R,5S,8R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-9-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-1-(4-methoxy-benzyloxy)-2,6,8-trimethyl-non-6-en-3-one 

Relevant academic research and scientific papers

Stereocontrol in asymmetric SE' reactions of γ-substituted α,β-unsaturated aldehydes

Asymmetric SE' reactions of (E)-and (Z)-γ-substituted-α,β- unsaturated aldehydes have been studied for the stereocontrolled preparation of nonracemic alcohols. Mild exchange reactions of allylic stannanes provide access to chiral 1,3-bis-(tolylsulfonyl)-4

α,ω-functionalized 2,4-dimethylpentane dyads and 2,4,6-trimethylheptane triads through asymmetric hydrogenation

A match made in heaven: All the possible stereoisomers of α,ω-functionalized 2,4-dimethylpentane dyad and 2,4,6-tri- methylheptane triad chirons (see picture; A and B, respectively; FG = functional group, PG = protecting group) can be reached by using a c

High ?-Face Selectivity in Anti Aldol Reactions of E-Enol Borinates from Chiral Alkoxymethyl Ketones: Stereocontrolled Synthesis of a C24-C32 Polyol Subunit of Rapamycin

Using (c-C6H11)2BCl/Et3N, the aldol reactions of the α-chiral alkoxymethyl ketones 5 and 6 with achiral aldehydes gives the 1,2-anti-2,4-anti adducts 7 and 8 in 83-95 percent yield with >/= 95 percent diastereoselectivity.This novel aldol reaction was applied to a concise and highly stereocontrolled synthesis of the C24-C32 subunit 9 of rapamycin (10).