1499167-06-4Relevant academic research and scientific papers
OLIGOMER COMPRISING EPIGALLOCATECHINS, AND MANUFACTURING METHOD THEREOF
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Paragraph 0103-0106, (2020/01/08)
PROBLEM TO BE SOLVED: To provide an oligomer obtained by polymerization of two or more epigallocatechins, and a manufacturing method thereof. SOLUTION: The oligomer is a compound represented by the general formula (VI) in the figure, where R1 to R23 are e
Structure-activity relationship of oligomeric flavan-3-ols: Importance of the upper-unit B-ring hydroxyl groups in the dimeric structure for strong activities
Hamada, Yoshitomo,Takano, Syota,Ayano, Yoshihiro,Tokunaga, Masahiro,Koashi, Takahiro,Okamoto, Syuhei,Doi, Syoma,Ishida, Masahiko,Kawasaki, Takashi,Hamada, Masahiro,Nakajima, Noriyuki,Saito, Akiko
, p. 18870 - 18885 (2015/11/27)
Proanthocyanidins, which are composed of oligomeric flavan-3-ol units, are contained in various foodstuffs (e.g., fruits, vegetables, and drinks) and are strongly biologically active compounds. We investigated which element of the proanthocyanidin structu
Syntheses of prodelphinidin B1, B2, and B4 and their antitumor activities against human PC-3 prostate cancer cell lines
Fujii, Wataru,Toda, Kazuya,Matsumoto, Kiriko,Kawaguchi, Koichiro,Kawahara, Sei-Ichi,Hattori, Yasunao,Fujii, Hiroshi,Makabe, Hidefumi
supporting information, p. 7188 - 7192 (2013/12/04)
Total synthesis of prodelphinidin B1, B2, and B4 has been accomplished. The key step is Lewis acid-mediated equimolar condensations between an epigallocatechin and/or a gallocatechin nucleophile and an epigallocatechin and/or a gallocatechin electrophile. The antitumor effects of synthetic prodelphinidin B1-B4 against human PC-3 prostate cancer cell lines have been investigated. These compounds showed significant antitumor effects. Their activity seemed to be little bit stronger than EGCG and prodelphinidin B3, known antitumor agent.
