149944-33-2Relevant academic research and scientific papers
Expedient synthesis of sulfinamides from sulfonyl chlorides
Harmata, Michael,Zheng, Pinguan,Huang, Chaofeng,Gomes, Maria G.,Ying, Weijiang,Ranyanil, Kanok-On,Balan, Gayatri,Calkins, Nathan L.
, p. 683 - 685 (2007/10/03)
Sulfinamides were synthesized from sulfonyl chlorides using a procedure involving in situ reduction of sulfonyl chlorides. The reaction is broad in scope and easy to perform.
A reversible safety-catch method for the hydrogenolysis of N-benzyl moieties
Johnson II, David C.,Widlanski, Theodore S.
, p. 8483 - 8487 (2007/10/03)
The benzyl groups of β-hydroxy-N-benzyl sulfonamides are labile toward hydrogenolysis-unlike N-benzyl sulfonamides lacking the β-hydroxy moiety. We find that N-acyl-N-benzyl sulfonamides undergo hydrogenolysis under very mild conditions. Based upon these observations, we developed a reversible safety-catch method using tert-butoxycarbonyl moieties to activate N-benzyl sulfonamides toward hydrogenolysis. We also explored the utility of the safety-catch activation method for other nitrogen-based functionality such as N-benzyl carboxamides, imides, and related functionality.
A Convenient Synthesis of 5-Substituted Tetrahydro-1,4,3-oxathiazine 4,4-Dioxides
Grunder-Klotz, Evelyne,Humbert, Paul,Ehrhardt, Jean-Daniel
, p. 733 - 742 (2007/10/02)
An adventageous one pot procedure for the synthesis of tetrahydro-1,4,3-oxathiazine 4,4-dioxides by dialkylation of readily available α,N-alkyl or arylsulfonamide dianions with gaseous formaldehyde is reported.Stability and some reactions of these heterocycles are also described.
