149949-30-4

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Difluoro-3-methoxyBenzaldehyde is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique chemical properties allow it to be a key component in the development of new drugs and medications.
Used in Chemical Synthesis:
2,6-Difluoro-3-methoxyBenzaldehyde is used as a building block in the synthesis of a wide range of organic compounds. Its versatility in chemical reactions makes it an essential component in the production of various chemicals and materials.
Used in Research and Development:
2,6-Difluoro-3-methoxyBenzaldehyde is used as a research compound for studying its chemical properties and potential applications. It serves as a valuable tool for scientists and researchers in the field of organic chemistry to explore new reactions and develop innovative applications.

InChI:InChI=1/C8H6F2O2/c1-12-7-3-2-6(9)5(4-11)8(7)10/h2-4H,1H3

Upstream product

• 2591-86-8 N-Formylpiperidine 
• 452-10-8 2,4-difluoro-1-methoxybenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 367-27-1 2,4-difluorophenol 

Downstream Products

• 1193351-06-2 2,4-dichloro-1-(4-chlorophenyl)-5-(2,6-difluoro-3-methoxyphenyl)-1H-imidazole 
• 1193348-78-5 4-chloro-1-(4-chlorophenyl)-5-(2,6-difluoro-3-methoxyphenyl)-1H-imidazole 
• 1453211-52-3 2-ethynyl-1,3-difluoro-4-methoxybenzene 
• 1193353-33-1 5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-2,4-dimethyl-1H-imidazole 
• 1193352-82-7 2,4-dibromo-5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-1H-imidazole 
• 1193352-37-2 4-bromo-5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-1H-imidazole 
• 1193512-04-7 2,6-difluoro-α-[(4-fluorophenyl)amino]-3-methoxybenzeneacetonitrile 
• 149489-26-9 2-(2,6-difluoro-3-methoxyphenyl)ethyl-amine 
• 886498-45-9 (2,6-difluoro-3-methoxyphenyl)methanol 

Relevant academic research and scientific papers

Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs

Phenylethylthiazolylthiourea (PETT) derivatives have been identified as a new series of nonnucleoside inhibitors of HIV-1 RT. Structure-activity relationship studies of this class of compounds resulted in the identification of N-[2-(2-pyridyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea hydrochloride (trovirdine; LY300046.HCl) as a highly potent anti-HIV-1 agent. Trovirdine is currently in phase one clinical trials for potential use in the treatment of AIDS. Extension of these structure-activity relationship studies to identify additional compounds in this series with improved properties is ongoing. A part of this work is described here. Replacement of the two aromatic moleties of the PETT compounds by various substituted or unsubstituted heteroaromatic rings was investigated. In addition, the effects of multiple substitution in the phenyl ring were also studied. The antiviral activities were determined on wild-type and constructed mutants of HIV-1 RT and on wild-type HIV-1 and mutant viruses derived thereof, Ile100 and Cys181, in cell culture assays. Some selected compounds were determined on double- mutant viruses, HIV-1 (Ile100/Asn103) and HIV-1 (Ile100/Cys181). A number of highly potent analogs were synthesized. These compounds displayed IC50's against wild-type RT between 0.6 and 5 nM. In cell culture, these agents inhibited wild-type HIV-1 with ED50's between I and 5 nM in MT-4 cells. In addition, these derivatives inhibited mutant HIV-1 RT (Ile 100) with IC50's between 20 and 50 nM and mutant HIV-1 RT (Cys 181) with IC50's between 4 and 10 nM, and in cell culture they inhibited mutant HIV-1 (Ile100) with ED50's between 9 and 100 nM and mutant HIV-1 (Cys181) with ED50's between 3 and 20 nM.

Synthesis and evaluation of the anti-mammary tumor activity and of the estrogenic side effects of platinum(II) complexes

The synthesis and structural characterization of mammary tumor-inhibiting, diastereomeric platinum(II) complexes with 2,6-Cl2, 2F, 6-Cl, 2-Cl, 6-F and 2,6-F2 substituents (1-PtSO4 to 4-PtSO4) are describ