15000-43-8

Basic information

• Product Name: 2-hydroxy-4-oxo-1H-quinoline-3-carbonitrile
• Synonyms: 2-hydroxy-4-oxo-1H-quinoline-3-carbonitrile;3-Cyano-2,4-dihydroxy-3-phenylquinoline;4-hydroxy-2-oxo-1H-quinoline-3-carbonitrile
• CAS NO: 15000-43-8
• Molecular Formula: C₁₀H₆N₂O₂
• Molecular Weight: 186.17
• Mol File: 15000-43-8.mol
• Article Data: 16

Chemical Properties

• Melting Point: 292-295 °C (decomp)
• Boiling Point: 304.6°Cat760mmHg
• Flash Point: 138°C
• Appearance: /
• Density: 1.47g/cm³
• Vapor Pressure: 0.000378mmHg at 25°C
• Refractive Index: 1.686
• PKA: 4.50±1.00(Predicted)
• CAS DataBase Reference: 2-hydroxy-4-oxo-1H-quinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-4-oxo-1H-quinoline-3-carbonitrile(15000-43-8)
• EPA Substance Registry System: 2-hydroxy-4-oxo-1H-quinoline-3-carbonitrile(15000-43-8)

Safety Data

• Hazardous Substances Data: 15000-43-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H6N2O2/c11-5-7-9(13)6-3-1-2-4-8(6)12-10(7)14/h1-4H,(H2,12,13,14)

Upstream product

• 118-48-9 isatoic anhydride 
• 105-56-6 ethyl 2-cyanoacetate 
• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 89-52-1 o-acetylamino-benzoic acid 
• 134-20-3 2-carbomethoxyaniline 
• 41470-88-6 2-ethoxy-4H-benzo[d][1,3]oxazin-4-one 
• 118-92-3 anthranilic acid 
• 103-71-9 phenyl isocyanate 
• 4336-70-3 (cyanomethyl)triphenylphosphonium chloride 
• 2651-12-9 ethyl 2-cyano-3-oxo-3-(phenylamino)-propanoate 
• 1026672-88-7 3-(2-Acetylamino-phenyl)-2-cyano-3-oxo-propionic acid ethyl ester 
• 1025941-86-9 3-(2-Acetylamino-phenyl)-2-cyano-3-oxo-propionic acid methyl ester 
• 154325-57-2 methyl 2-(2-cyanoacetamido)benzoate 
• 122807-12-9 ethyl N-<2-(bromoacetyl)phenyl>carbamate 

Downstream Products

• 69875-54-3 2,4-Dichloroquinoline-3-carbonitrile 
• 680210-85-9 4-chloro-2-oxo-1,2-dihvdroquinoline-3-carbonitrile 
• 16560-18-2 4-phenyl-2-oxo-1,2-dihydroquinoline-3-carbonitrile 
• 18714-34-6 2-nitro-quinoline 
• 212378-26-2 2-chloro-4-(triphenylphosphoranylideneamino)quinoline-3-carbonitrile 
• 157027-31-1 4-azido-2-chloroquinoline-3-carbonitrile 
• 876134-48-4 2,4-bis(triphenylphosphoranylideneamino)quinoline-3-carbonitrile 
• 876134-51-9 5-(triphenylphosphoranylideneamino)tetrazolo[1,5-a]quinoline-4-carbonitrile 
• 876134-52-0 4-amino-2-triphenylphosphoranylideneaminoquinoline-3-carbonitrile 

Relevant articles and documents

Remarkably efficient and direct route to quinolines and benzoazepines from the condensation of benzoxazinediones with phosphonium carbanion salts

Treatment of 2H-3,1-benzoxazine-2,4(1H)-dione (1a) with vinyltriphenylphosphonium bromide (2a) gives substituted benzoazepine 8a (48% yield) and indolizinone 12 (27% yield), whereas substituted quinolinone 15 and benzoazepine 8b were isolated from the rea

4-HYDROXY-2-QUINOLONES. 18. SYNTHESIS AND ANTITHYROID ACTIVITY OF 1-R-2-OXO-3-(4-OXO-3H-QUINAZOLIN-2-YL)-4-HYDROXYQUINOLINES

Preparative methods for the synthesis of 1-R-2-oxo-3-(4-oxo-3H-quinazolin-2-yl)-4-hydroxyquinolines based on ethyl esters or nitriles of 1-R-2-oxo-4-hydroxyquinoline-3-carboxylic acids and anthranilamide or ethyl anthranilate correspondingly were proposed

PHENYL-CYANOQUINOLINONE PDE9 INHIBITORS

The present invention is directed to phenylcyanoquinolinone compounds which may be useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 9 (PDE9). The present invention also relates to the use

OXY-CYANOQUINOLINONE PDE9 INHIBITORS

The present invention is directed to oxycyanoquinolinone compounds which may be useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 9 (PDE9). The present invention also relates to the use of