150017-54-2Relevant academic research and scientific papers
Nitropyrazoles 4. N-Amination under control of the pH of the medium
Vinogradov, V. M.,Dalinger, I. L.,Gulevskaya, V. I.,Shevelev, S. A.
, p. 1369 - 1371 (2007/10/02)
A preparative method of N-amination of pyrazoles bearing nitro groups and other electron withdrawing substituents in the pyrazole ring with hydroxylamine-O-sulfonic acid involving control of the pH of the medium has been elaborated.A series of previously unknown pyrazoles has been prepared.Basicities (pKBH+) of 1-aminopyrazole and 1-amino-4-nitropyrazole have been measured and differences between the basicities of the C- and N-amino groups for the pyrazole series have been revealed. - Key words: nitropyrazoles, N-aminopyrazoles, N-amination.
