150097-80-6

Basic information

• Product Name: 4-(4-Chloro-2-phenylacetylamino-phenyl)-4-oxo-butyric acid ethyl ester
• CAS NO: 150097-80-6
• Molecular Weight: 373.836
• Mol File: 150097-80-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-Chloro-2-phenylacetylamino-phenyl)-4-oxo-butyric acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Chloro-2-phenylacetylamino-phenyl)-4-oxo-butyric acid ethyl ester(150097-80-6)
• EPA Substance Registry System: 4-(4-Chloro-2-phenylacetylamino-phenyl)-4-oxo-butyric acid ethyl ester(150097-80-6)

Safety Data

• Hazardous Substances Data: 150097-80-6(Hazardous Substances Data)

Upstream product

• 1026433-37-3 Phenyl-acetic acid 4-chloro-2-phenylacetylamino-benzyl ester 
• 150097-77-1 N-(Benzylcarbonyl)-5-chloro-2-hydroxymethylaniline 
• 150097-78-2 2-(Benzylcarbonylamino)-4-chloro benzaldehyde 
• 37585-16-3 (2-amino-4-chlorophenyl)methanol 
• 150097-79-3 4-(4-Chloro-2-phenylacetylamino-phenyl)-4-hydroxy-butyric acid ethyl ester 

Downstream Products

• 150097-64-6 7-chloro-4-(2-methoxycarbonylethyl)-3-phenyl-2(1H)-quinolone 
• 150097-65-7 4-(2-aminocarbonylethyl)-7-chloro-3-phenyl-2(1H)-quinolone 
• 150097-63-5 4-(2-carboxyethyl)-7-chloro-3-phenyl-2(1H)-quinolone 
• 150097-66-8 7-chloro-4-(2-cyanoethyl)-3-phenyl-quinolin-2(1H)-one 
• 150097-81-7 7-chloro-4-[(2-ethoxycarbonyl)ethyl]-3-phenyl-2(1H)-quinolone 

Relevant articles and documents

4-Substituted-3-phenylquinolin-2(1H)-ones: Acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity

4-Substituted-3-phenylquinolin-2(1H)-ones have been synthesized and evaluated in vitro for antagonist activity at the glycine sits on the NMDA (N-methyl-D-aspartate) receptor and in vivo for anticonvulsant activity in the DBA/2 strain of mouse in an audiogenic seizure model. 4-Amino-3- phenylquinolin-2(1H)-one (3) is 40-fold lower in binding affinity but only 4- fold weaker as an anticonvulsant than the acidic 4-hydroxy compound 1. Methylsulfonylation at the 4-position of 3 gives an acidic compound (6, pK(a) = 6.0) where affinity is fully restored but in vivo potency is significantly reduced (Table 1). Methylation at the 4-position of 1 to give 18 results in the abolition of measurable affinity, but the attachment of neutral hydrogen bond-accepting groups to the methyl group of 18 produces compounds with comparable in vitro and in vivo activity to 1 (e.g., 23 and 28, Table 2). Replacement of the 4-hydroxy group of 1 with an ethyl group abolishes activity (42), but again, incorporation of neutral hydrogen bond acceptors to the terminal carbon atom restores affinity (e.g., 36, 39, and 40, Table 3). Replacement of the 4-hydroxy group of the high-affinity compound 2 with an amino group produces a compound with 200-fold reduced affinity (43, IC50 = 0.42 μM, Table 4) which is nevertheless still 10-fold higher in affinity than 3. The results in this paper indicate that anionic functionality is not an absolute requirement for good affinity at the glycine/NMDA site and provide compelling evidence for the existence of a ligand/receptor hydrogen bond interaction between an acceptor attached to the 4-position of the ligand and a hydrogen bond donor attached to the receptor.