150108-66-0Relevant articles and documents
Synthesis of thienopyridinones via hydrazide-alkyne cyclization
Balci, Metin,Cokol, Nalan Korkmaz,Dengiz, Cagatay,Erden, Kübra,Gunay, Furkan Melih
, (2020/04/08)
A novel and efficient method for the synthesis of thieno[3,2-c]pyridinones have been developed. The synthetic strategy relies on the synthesis of halothiophene esters utilized as substrates for subsequent Sonogashira cross-coupling reactions. Hydrazinolysis of corresponding esters and following hydrazide-alkyne ring closure transformations resulted in target thienopyridinones in good yields. It is also shown that pure hydrazine monohydrate is required to facilitate the hydrazide formations.
COMPOUNDS FOR TREATING VIRAL INFECTIONS
-
Page/Page column 76; 78, (2015/11/09)
The present invention relates to small molecule compounds and their use in the treatment of diseases, in particular viral diseases, in particular hepatitis C virus (HCV).