150114-69-5

Basic information

• Product Name: 3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE
• Synonyms: 3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE;3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE , DRY WT. BASIS;3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE, 98%, DRY WT. BASIS;3,4,5-Trimethoxyphenylglyoxal hydrate , 97+%;3,4,5-Trimethoxyphenylglyoxal;Benzeneacetaldehyde, 3,4,5-trimethoxy-α-oxo-
• CAS NO: 150114-69-5
• Molecular Formula: C₁₁H₁₂O₅
• Molecular Weight: 242.23
• EINECS: -0
• Mol File: 150114-69-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 128-131°C
• Boiling Point: 424.8°Cat760mmHg
• Flash Point: 210.7°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 5.63E-08mmHg at 25°C
• BRN: 3733165
• CAS DataBase Reference: 3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE(150114-69-5)
• EPA Substance Registry System: 3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE(150114-69-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 150114-69-5(Hazardous Substances Data)

Usage

General Description

3,4,5-Trimethoxyphenylglyoxal hydrate, also known as 3,4,5-trimethoxybenzene-1,2-dicarbaldehyde hydrate, is a chemical compound with the molecular formula C11H14O5. It is a white to off-white crystalline powder that is soluble in water and organic solvents. 3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE is often used as a building block in the synthesis of pharmaceuticals, dyes, and other organic compounds. It is also used in research laboratories as a reagent in chemical reactions. 3,4,5-Trimethoxyphenylglyoxal hydrate is known for its ability to form stable and functionalized structures, making it a valuable component in the field of organic chemistry and drug development.

InChI:InChI=1/C11H12O5.H2O/c1-14-9-4-7(8(13)6-12)5-10(15-2)11(9)16-3;/h4-6H,1-3H3;1H2

Upstream product

• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 1374568-30-5 2,2-diiodo-1-(3,4,5-trimethoxyphenyl)ethanone 
• 1374568-07-6 2,2-diiodo-1-(3,4,5-trimethoxyphenyl)ethanol 

Downstream Products

• 1374568-40-7 2-(3,4,5-trimethoxyphenyl)benzopyrazine 

Relevant articles and documents

Design, synthesis, and biological evaluation of hydantoin bridged analogues of combretastatin A-4 as potential anticancer agents

A series of novel hydantoin-bridged analogues of combretastatin A-4 (CA-4) were designed, synthesized and evaluated for antiproliferative activities in vitro and in vivo. The most potent compound 8d, showed potent cytotoxicity against four human cancer cell lines with IC50 values of 0.186–0.279 μM, and possessed the efficacy of inhibiting tubulin polymerization, disrupting in vitro vascularization, blocking cell cycle in G2/M phase and inducing cell apoptosis. In the nude mice xenograft model, 8d significantly inhibited the tumor growth and showed low toxicity. Further chiral separation proved (R)-(?)-8d to be the preferential enantiomer with IC50 values of 0.081–0.157 M. These results indicated that the hydantoin derivatives merit further investigation as potential anticancer agents that inhibit tubulin polymerization.

Unexplored reactivity of 2-oxoaldehydes towards Pictet-Spengler conditions: Concise approach to β-carboline based marine natural products

Novel reactions under Pictet-Spengler conditions between tryptophan methyl ester/tryptamine and 2-oxoaldehydes have been developed and successfully utilized for the total synthesis of Merinacarboline (A and B), Eudistomin Y1, Pityriacitrin B, Pityriacitrin, Fascaplysin and analogues.