1501153-29-2Relevant academic research and scientific papers
One-pot peptide ligation-desulfurization at glutamate
Cergol, Katie M.,Thompson, Robert E.,Malins, Lara R.,Turner, Peter,Payne, Richard J.
supporting information, p. 290 - 293 (2014/01/23)
An efficient methodology for ligation at glutamate (Glu) is described. A γ-thiol-Glu building block was accessed in only three steps from protected glutamic acid and could be incorporated at the N-terminus of peptides. The application of these peptides in one-pot ligation-desulfurization chemistry is demonstrated with a range of peptide thioesters, and the utility of this methodology is highlighted through the synthesis of the osteoporosis peptide drug teriparatide (Forteo).
