15014-20-7Relevant academic research and scientific papers
Environmentally benign decarboxylative: N-, O-, and S-Acetylations and acylations
Ghosh, Santanu,Purkait, Anisha,Jana, Chandan K.
, p. 8721 - 8727 (2020/12/30)
An operationally simple and general method for acetylation and acylation of a wide variety of substrates (amines, alcohols, phenols, thiols, and hydrazones) has been reported. Meldrum's acid and its derivatives have been used as an air-stable, non-volatile, cost-effective, and easy to handle acetylating/acylating agent. Easily separable byproducts (CO2 and acetone) allowed the isolation of analytically pure acetylated products without the requirement of work-up and any chromatography. This journal is
Asymmetric catalytic 1,6-conjugate addition/aromatization of para-quinone methides: Enantioselective introduction of functionalized diarylmethine stereogenic centers
Chu, Wen-Dao,Zhang, Le-Fen,Bao, Xu,Zhao, Xian-He,Zeng, Chao,Du, Ji-Yuan,Zhang, Guo-Biao,Wang, Fang-Xin,Ma, Xiao-Yan,Fan, Chun-An
supporting information, p. 9229 - 9233 (2013/09/12)
It′s just a phase: The title reaction sequence of para-quinone methides (p-QMs) has been developed with malonates under phase-transfer catalysis. The reaction also offers an alternative route to asymmetric construction of diarylmethine stereocenters in ex
Facile synthesis of novel pyrimido[1,2-a]pyrimidin-4-ones from highly reactive malonates
Guellue, Mustafa,Dincsoenmezl, Ali,Oezyavas, Oeznur
experimental part, p. 2113 - 2120 (2010/06/15)
A very simple and efficient procedure for the synthesis of novel 2-hydrox.y-4H-pyrimido[1,2-a]pyrimidin-4-ones is described. Title compounds were obtained from the room temperature reaction of 2-aminopyrimidine and its substituted derivatives with bis(2,4,6-trichlorophenyl) malonates. High product yields were observed under optimized conditions. Applicability and reactivity of a range of substituted and unsubstituted phenyl malonates were also investigated. Structural identification of all new compounds was accomplished by spectroscopic methods and elemental analysis.
Highly enantioselective introduction of bis(alkoxycarbonyl)methyl group into the 2-position of piperidine skeleton
Matsumura, Yoshihiro,Minato, Diashirou,Onomura, Osamu
, p. 654 - 663 (2008/02/06)
Copper ion catalyzed carbon-carbon bond forming reaction of N-acyliminium ions with diaryl malonates was achieved with high enantioselectivity. The key intermediates in the method were 2-methoxy-3,4-didehydropiperidines, which were easily prepared through
