15017-44-4Relevant articles and documents
Tetrahydroisoquinoline-Based Non-Peptidomimetic Plasmepsin Inhibitors
Kinena, Linda,Ozola, Vita
, p. 60 - 66 (2020/02/18)
[Figure not available: see fulltext.] A series of tetrahydroisoquinoline derivatives containing different aryl substituents were designed and synthesized using Pictet–Spengler reaction as the key step. The synthesized tetrahydroisoquinoline derivatives di
Organocatalytic Enantioselective Addition of α-Aminoalkyl Radicals to Isoquinolines
Liu, Xiangyuan,Liu, Yang,Chai, Guobi,Qiao, Baokun,Zhao, Xiaowei,Jiang, Zhiyong
supporting information, p. 6298 - 6301 (2018/10/09)
With a dual organocatalytic system involving a chiral phosphoric acid and a dicyanopyrazine-derived chromophore (DPZ) photosensitizer and under the irradiation with visible light, an enantioselective Minisci-type addition of α-amino acid-derived redox-active esters (RAEs) to isoquinolines has been developed. A variety of prochiral α-aminoalkyl radicals generated from RAEs were successfully introduced on isoquinolines, providing a range of valuable α-isoquinoline-substituted chiral secondary amines in high yields with good to excellent enantioselectivities.
Hydroxyethylene sulfones as a new scaffold to address aspartic proteases: Design, synthesis, and structural characterization
Specker, Edgar,B?ttcher, Jark,Heine, Andreas,Sotriffer, Christoph A.,Lilie, Hauke,Schoop, Andreas,Müller, Gerhard,Griebenow, Nils,Klebe, Gerhard
, p. 6607 - 6619 (2007/10/03)
Hydroxyethylene sulfones were developed as novel scaffolds against aspartyl proteases. A diastereoselective synthesis has been established to introduce the required side chain decoration with desired stereochemistry. Depending on the substitution of the h
Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists
Bigge,Drummond,Johnson,Malone,Probert Jr.,Marcoux,Coughenour,Brahce
, p. 1580 - 1590 (2007/10/02)
To investigate the preferred spatial relationship of the distal phosphonic acid to the α-amino acid group of the established competitive N-methyl-D-aspartic acid (NMDA) antagonists APH (1) and APV (2), we have prepared a series of ortho-, meta-, and para-
