150194-53-9Relevant articles and documents
PROCESS FOR PREPARING BIOLOGICALLY ACTIVE DERIVATIVES OF 1,2,4-TRIAZOL AND INTERMEDIARIES USEFUL IN THIS PROCESS
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, (2008/06/13)
A process for the preparation of fluconazole, which is a well blown antifungal agent, and of pharmaceutically acceptable salts thereof is disclosed, wherein a novel compound of the formula (IV) wherein R represents H, benzyl, triphenylmethyl and COOR1with R1being alkyl or aryl, preferably tert-butyl or ethyl, and Z represents a triazole radical or hydrazine radical optionally substituted by R being defined as above, optionally in the salt form, is reacted with s-triazine. The novel compound (IV) is an object of the invention as well.