15023-79-7Relevant academic research and scientific papers
Highly chemo-, enantio-, and regioselective synthesis of α,α-disubstituted furanones by Cu-catalyzed conjugate addition
Endo, Kohei,Yakeishi, Sayuri,Takayama, Ryotaro,Shibata, Takanori
supporting information, p. 8893 - 8897 (2014/07/22)
A highly chemo-, enantio-, and regioselective synthesis of furanones bearing an α,α-disubstituted quaternary stereogenic center is reported. The Cu-catalyzed enantioselective conjugate addition of organoaluminum reagents to unsaturated ketoesters at room temperature and subsequent lactonization took place. Synthetic transformations of furanones represent facile approaches to various cyclic or acyclic compounds bearing a quaternary stereogenic center. Selective chemistry: A highly chemo-, enantio-, and regioselective synthesis of furanones bearing an α,α-disubstituted quaternary stereogenic center is reported (see scheme). Cu-catalyzed enantioselective conjugate addition of organoaluminum reagents to unsaturated ketoesters at room temperature and subsequent lactonization took place.
Activation of 1,2-keto esters with Takemoto's catalyst toward michael addition to nitroalkenes
Raimondi, Wilfried,Basle, Olivier,Constantieux, Thierry,Bonne, Damien,Rodriguez, Jean
supporting information; experimental part, p. 563 - 568 (2012/04/17)
When activated with Takemoto's catalyst, 1,2-keto esters constitute versatile nucleophiles in the Michael addition reaction with nitroalkenes affording synthetically valuable, optically active anti-adducts in very good yields and high enantiomeric excesses. Copyright
Modulators of LXR
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, (2008/06/13)
Compounds of the invention, such as compounds of formula (I): where n, m, A, B, R1, R2, R3, R4 and R5 are defined herein, are useful as modulators of the activity of liver X receptors. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
