150281-86-0

Upstream product

• 67580-96-5 benzyl (2-hydroxyethyl)methylcarbamate 
• 107-06-2 1,2-dichloro-ethane 
• 572-09-8 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 604-69-3 β-D-glucose pentaacetate 

Relevant academic research and scientific papers

CuII and AuIII Complexes with Glycoconjugated Dithiocarbamato Ligands for Potential Applications in Targeted Chemotherapy

This work is focused on the synthesis, characterization, and preliminary biological evaluation of bio-conjugated AuIII and CuII complexes with the aim of overcoming the well-known side effects of chemotherapy by improving the selective accumulation of an anticancer metal payload in malignant cells. For this purpose, carbohydrates were chosen as targeting agents, exploiting the Warburg effect that accounts for the overexpression of glucose-transporter proteins (in particular GLUTs) in the phospholipid bilayer of most neoplastic cells. We linked the dithiocarbamato moiety to the C1 position of three different monosaccharides: d-glucose, d-galactose, and d-mannose. Altogether, six complexes with a 1:2 metal-to-ligand stoichiometry were synthesized and in vitro tested as anticancer agents. One of them showed high cytotoxic activity toward the HCT116 colorectal human carcinoma cell line, paving the way to future in vivo studies aimed at evaluating the role of carbohydrates in the selective delivery of whole molecules into cancerous cells.

Phenothiazinium salts and their use for disinfecting aqueous effluents

Novel 3,7-disubstituted phenothiazinium salts are active in the photochemical disinfection of aqueous effluents. The novel salts are of the general formula STR1 wherein: either R1 is a saccharide residue; R2 is alkyl, cycloalkyl, aryl, aralkyl or heterocyclyl, any alkyl or alkylene chain being optionally interrupted by one or more heteroatoms, and Y is alkylene optionally substituted by alkyl, cycloalkyl, aryl or aralkyl; or R1 and R2 are each methyl and Y is a bond; and when R1 is a saccharide residue X is an anion selected from halogen, R3 CO2-, R3 SO3- and R3 OSO3-, wherein R3 is alkyl, cycloalkyl, aryl, aralkyl or heterocyclyl, and when R1 and R2 are each methyl, X is an anion selected from R3 SO3-, R3 OSO3- wherein R3 is as defined above and R4 CO2-, wherein R4 is an aldose or ketose residue, an N-protected α-amino acid residue or a ω-carboxy-α-amino acid residue.