15029-26-2

Usage

Uses

Used in Pharmaceutical Research:
2-CYANO-N-(2-MORPHOLIN-4-YL-ETHYL)-ACETAMIDE is used as a research compound for the development of new drugs, leveraging its unique structural features to explore potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic chemistry, 2-CYANO-N-(2-MORPHOLIN-4-YL-ETHYL)-ACETAMIDE is used as a synthetic intermediate for the creation of other organic compounds, contributing to the advancement of chemical libraries and the discovery of novel chemical entities.

InChI:InChI=1/C9H15N3O2/c10-2-1-9(13)11-3-4-12-5-7-14-8-6-12/h1,3-8H2,(H,11,13)

Upstream product

• 2038-03-1 4-(2-AMINOETHYL)MORPHOLINE 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 117194-86-2 (E)-3-(2-tert-Butylsulfanyl-phenyl)-2-cyano-N-(2-morpholin-4-yl-ethyl)-acrylamide 
• 115-11-7 isobutene 

Relevant academic research and scientific papers

Structure-activity relationship of spop inhibitors against kidney cancer

Speckle-type POZ protein (SPOP) is overexpressed in the nucleus and misallocated in the cytoplasm in almost all the clear-cell renal cell carcinomas (ccRCCs), which leads to kidney tumorigenesis. Previously, we elucidated that the oncogenic SPOP-signaling pathway in ccRCC could be suppressed by 6b that inhibits SPOP-mediated protein interactions. Herein, we have established a structure-activity relationship for 6b analogues as SPOP inhibitors. Compound 6lc suppresses the viability and inhibits the colony formation of ccRCC cell lines driven by cytoplasmic SPOP, superior to 6b. Compound 6lc binds to the SPOP protein in vitro and disrupts SPOP binding to phosphatase-and-tensin homologue (PTEN) in HEK293T cells, which causes the observable phenomena: a decline in the ubiquitination of PTEN, elevated levels of both PTEN and dual-specificity phosphatase 7, and decreased levels of phosphorylated AKT and ERK when ccRCC cell lines are exposed to 6lc in a dose-response manner. Taken together, compound 6lc is a potent candidate against kidney tumorigenesis.

Sur le mecanisme de la Reaction de Meth-Cohn-Tarnowski de preparation des thiocoumarines

Reaction of 2-t-butylthiobenzaldehyde with N-(2-dialkylaminoethyl)-cyanacetamides followed by heating of the resulting 3-(2-t-butylthiophenyl)-2-cyanoacrylamides in polyphosphoric acid leads to the formation of 3-carboxamido-2-imino-2H-benzothiopyrane intermediates which afford thiocoumarins on hydrolysis.The authors postulate the intermediate formation of a thiophenate ion by an electronic mechanism involving six centers.