1503-43-1

Upstream product

• 49845-05-8 1-cyano-1-methoxycarbonyl-4-amino-4-phenyl-2-aza-1,3-butadiene 
• 49845-04-7 1-cyano-1-methoxycarbonyl-3-methyl-4-amino-4-phenyl-2-aza-1,3-butadiene 
• 28643-16-5 3-amino-5-chloro-pyrazine-2-carboxylic acid methyl ester 
• 98-80-6 phenylboronic acid 
• 68884-06-0 2-amino-6-phenylpyrazine-3-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 1634-22-6 C₁₂H₁₂N₆O 
• 41270-60-4 3-oxo-5-phenyl-3,4-dihydro-pyrazine-2-carboxylic acid 

Relevant academic research and scientific papers

INHIBITORS OF FATTY ACID BINDING PROTEIN

The present invention relates to novel heterocyclic compounds as Fatty Acid Binding Protein (“FABP”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.

Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3)

A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain.

2-Aza-1,3-dienes. A New Approach to Substituted 2-Aminopyrazines

Treatment of enamines by tosylated isonitrosomalono derivatives gives access to 5-dialkylamino-1,1-dicyano 2-aza-1,3-dienes (or 1-methoxycarbonyl analogous) which are precursors of various regiospecific 5,6-substituted 2-amino-3-cyano (or methoxycarbonyl) pyrazines.Some examples of utilisation of these intermediates for synthesis of lumazines, pteridines, and other bicyclic skeletons are described.

Process for making pyrazines from 2-aza-1,3-butadienes

Process for the preparation of an amino-pyrazine falling within the formula: SPC1 In which R1 and R2 each represent a hydrogen atom, or an alkyl or aryl group, or together with the carbon atoms of the pyrazine ring form a cyclic hydrocarbon having 5 to 7 carbon atoms, and X represents a cyano, carboxy, carbonamido, alkoxy-carbonyl or aryloxycarbonyl group which comprises subjecting a 2-aza-1,3-butadiene of the general formula: EQU1 wherein Z and Zi each represent an alkyl group or together with the nitrogen atom form a heterocyclic compound possibly containing another hetero atom to the action of ammonia and reacting the 4-amino-2-aza-1,3-butadiene of formula EQU2 thus obtained with a basic agent: novel compounds of formula VIII in which R1 and R2 each represent a different alkyl or aryl group or together with the carbon atoms of the pyrazine ring form a cyclic hydrocarbon containing 5 to 7 carbon atoms: intermediate compounds of formula: EQU3 wherein X, R1 and R2 have the meanings given above and Z and Z' each represent an alkyl group or together with the nitrogen atom form a heterocyclic compound possibly containing another hetero-atom; and intermediate compounds of the formula: EQU4 wherein X, R1 and R2 have the meanings given above.