1503-68-0Relevant articles and documents
Targeting the Warburg Effect in cancer; Relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3)
Brooke, Darby G.,Van Dam, Ellen M.,Watts, Colin K.W.,Khoury, Amanda,Dziadek, Marie A.,Brooks, Hilary,Graham, Lisa-Jane K.,Flanagan, Jack U.,Denny, William A.
, p. 1029 - 1039 (2014/02/14)
High-throughput screening of a small-molecule library identified a 5-triazolo-2-arylpyridazinone as a novel inhibitor of the important glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3) Such inhibitors are of interest due to PFKFB3's
A "click and activate" Approach in one-pot synthesis of a triazolyl-pyridazinone library
Qian, Wenyuan,Winternheimer, David,Allen, Jennifer
supporting information; experimental part, p. 1682 - 1685 (2011/05/03)
A "click and activate" strategy was designed and executed in a four-component, stepwise condensation that led to a trisubstituted triazolyl-pyridazinone library. This one-pot process included regioselective azide substitution at 2-substituted-4,5-dichloro