15033-86-0Relevant academic research and scientific papers
Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR exploration and effective bioisosteric replacement of a phenyl substituent
Myers, Michael R.,He, Wei,Hanney, Barbara,Setzer, Natalie,Maguire, Martin P.,Zulli, Allison,Bilder, Glenda,Galzcinski, Helen,Amin, Dilip,Needle, Saul,Spada, Alfred P.
, p. 3091 - 3095 (2003)
Novel substituted 2-anilino- and 2-cycloalkylaminoquinoxalines have been found to be useful and selective inhibitors of PDGF-R autophosphorylation. Replacement of an anilino-substituent with substituted cyclohexylamino- or norbornylamino substituents led
Nucleophilic substitution on 2-monosubstituted quinoxalines giving 2,3-disubstituted quinoxalines: Investigating the effect of the 2-Substituent
Ndlovu, Ndumiso Thamsanqa,Nxumalo, Winston
, (2016/11/02)
An investigation on the effect of substituent at the 2-position of mono-substituted quinoxalines in the synthesis of di-substituted quinoxaline derivatives via nucleophilic substitution reactions, is reported. Di-substituted quinoxalines bearing aryl-Alky
Microwave-assisted synthesis of quinoline, isoquinoline, quinoxaline and quinazoline derivatives as CB2 receptor agonists
Saari, Raimo,T?rm?, Jonna-Carita,Nevalainen, Tapio
experimental part, p. 939 - 950 (2011/03/19)
Quinoline, isoquinoline, quinoxaline, and quinazoline derivatives were synthesized using microwave-assisted synthesis and their CB1/CB2 receptor activities were determined using the [35S]GTPγS binding assay. Most of the prepared quinoline, isoquinoline, and quinoxalinyl phenyl amines showed low-potency partial CB2 receptor agonists activity. The most potent CB2 ligand was the 4-morpholinylmethanone derivative (compound 40e) (-log EC 50 = 7.8; Emax = 75%). The isoquinolin-1-yl(3- trifluoromethyl-phenyl)amine (compound 26c) was a high efficacy CB2 agonist (-log EC50 = 5.8; Emax = 128%). No significant CB1 receptor activation or inactivation was shown in these studies, except 40e, which showed weak CB1 agonist activity (CB1 -log EC50 = 5.0). These ligands serve as novel templates for the development of selective CB2 receptor agonist.
Bromination, Hydrolysis and Oxidation of 1-Phenyl-1H-pyrazoloquinoxaline (1-Phenylflavazole)
Pillai, P. Madhavan,Ramabhadran, P.
, p. 215 - 217 (2007/10/02)
Bromination of 1-phenylflavazole (1-phenyl-1H-pyrazoloquinoxaline) (1) and 1,3-diphenylflavazole (2) gives a single product in each case, the bromination taking place at para-position of the 1-phenyl group.Hydrolysis of 1 with NaOH or NaBH4 in boil
