150336-90-6

Usage

InChI:InChI=1/C15H20N2/c1-2-8-17-9-4-7-15(12-17)14-6-3-5-13(10-14)11-16/h3,5-6,10,15H,2,4,7-9,12H2,1H3

Upstream product

• 79412-56-9 3-(3-carbamoylphenyl)-N-n-propylpiperidine hydrochloride 
• 146820-21-5 3-<3-(methoxycarbonyl)phenyl>-N-n-propylpiperidine 
• 28987-79-3 m-tolylmagnesium bromide 
• 4385-77-7 3-(pyridine-3-yl)benzoic acid 
• 79601-27-7 3-pyridin-3-yl-benzoic acid methyl ester 
• 4385-67-5 3-(3-methylphenyl)pyridine 
• 626-55-1 3-Bromopyridine 
• 369650-37-3 3-(4-hydroxy-1-hydroxymethyl-butyl)-benzonitrile 

Relevant academic research and scientific papers

A rapid and general access to 3-arylpiperidines

A short and efficient synthetic sequence to produce a wide variety of 3-arylpiperidines from three simple building blocks is described. The key step is a palladium-catalyzed arylation of cyclopentene.

3-Phenylpiperidines. Central Dopamine-Autoreceptor Stimulating Activity

Thirty compounds related to the selective dopamine-autoreceptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine have been synthesized and tested for central dopamine-autoreceptor stimulating activity.The 3-(3-hydroxyphenyl)piperidine moiety seems indispensable for high potency and selectivity.Introduction of an additional hydroxyl group into the 4-position of the aromatic ring gives a compound with dopaminergic activity but lacking selectivity for autoreceptors. 3-(3-Hydroxyphenyl)-N-n-propylpyrrolidine, 3-(3-hydroxy)-N-n-propylperhydroazepine, and 3-(3-hydroxyphenyl)quinuclidine were all inactive.The most potent compounds were the N-isopropyl-, N-n-butyl-, N-n-pentyl-, and N-phenethyl-substituted 3-(3-hydroxyphenyl)piperidine derivatives.None of the compounds investigated seemed to have central noradrenaline- or serotonin-receptor stimulating activity.