150389-84-7

Usage

Uses

Used in Medicinal Chemistry:
10-(Oxiran-2-ylMethyl)acridin-9(10H)-one is used as a potential pharmaceutical candidate for the development of new drugs due to its unique chemical structure and reactivity.
Used in Material Science:
10-(Oxiran-2-ylMethyl)acridin-9(10H)-one is used as a building block for the synthesis of new materials with specific properties, such as polymers, coatings, and adhesives, due to its reactive oxirane group.
Used in Organic Synthesis:
10-(Oxiran-2-ylMethyl)acridin-9(10H)-one is used as an intermediate in the synthesis of other organic compounds, taking advantage of its reactivity and the ability to form new chemical bonds.
Further research and exploration of the properties and potential uses of 10-(Oxiran-2-ylMethyl)acridin-9(10H)-one are necessary to fully understand its capabilities and potential benefits in various industries.

Upstream product

• 578-95-0 10H-acridin-9-one 
• 106-89-8 epichlorohydrin 
• 91-40-7 2-(phenylamino)benzoic acid 
• 62-53-3 aniline 
• 118-91-2 ortho-chlorobenzoic acid 
• 2516-33-8 Cyclopropylmethanol 

Downstream Products

• 1304982-32-8 10-[3-((4-aminobenzyl)amino)-2-hydroxypropyl]-10H-acridin-9-one 

Relevant academic research and scientific papers

Search for MDR modulators: Design, syntheses and evaluations of N-substituted acridones for interactions with p-glycoprotein and Mg2+

By combining the structural features of acridone based anti-cancer drugs (like amsacrine) and MDR modulator propafenone, acridones with hydroxyl amine chain at N-10 have been designed and synthesized. These molecules exhibit appreciable interactions with p-gp and Mg2+ indicating their suitability to modulate p-gp mediated multi drug resistance.

Design, synthesis and evaluations of acridone derivatives using Candida albicans-Search for MDR modulators led to the identification of an anti-candidiasis agent

In order to search for MDR modulators, rationally designed acridone derivatives were investigated for their effect on influx or efflux of Rhodamine6G (R6G) in CAI4 cells. Results of these investigations indicate that in presence of compound 12, inhibition of growth of CAI4 cells and also an increased influx/efflux of R6G in CAI4 cells have been observed. This seems to be occurring due to the cell wall rupturing of Candida albicans. Compound 12 may be a suitable candidate for candidiasis therapy.

A fluorescent probe for estimation of adenosine diphosphate and monitoring of glucose metabolism

An ADP selective fluorescent probe working in aqueous medium was identified and the change in fluorescence as a function of ADP concentration was standardized. Using this probe, all the steps of glycolysis coupled with ATP/ADP inter-conversion and oxidative breakdown of pyruvate in the mitochondria were monitored and the consumption/production of ATP/ADP at each step was quantified. The quantity of ADP present in the mitochondria, taken from different body parts of a pig, was also determined. It is hypothesized that an appropriate modification of the technique may provide a diagnostic tool for monitoring biochemical pathways as well as for quick estimation of ADP in the mitochondria and other cell organelles.

ATP selective acridone based fluorescent probes for monitoring of metabolic events

Acridones carrying an appropriate substituent at N-10 showed significant fluorescence changes on interacting with ATP in HEPES buffer at pH 7.2. The selectivity and sufficient binding of these probes with ATP could be useful for monitoring of metabolic processes.