150399-28-3

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 57-13-6 urea 
• 1242772-21-9 1-(2-nitrophenyl)-3-(2-aminophenyl)urea 
• 3320-86-3 2-nitrophenyl isocyanate 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 916309-26-7 1,3-bis-(2-(3-nitro)-benzanilide-phenyl)-urea 
• 51815-55-5 1,3-bis-(2-benzamidophenyl)urea 
• 916309-25-6 1,3-bis-(2-(3-amino)-benzanilide-phenyl)-urea 
• 1007394-21-9 N,N'-(2,2'-carbonylbis(azanediyl)bis(2,1-phenylene))dibenzenesulfonamide 
• 1242772-16-2 C₂₇H₂₂N₈O₇ 
• 1355975-94-8 1,3-bis[2-(2-aminophenyl)urea-phenyl]-urea 
• 1355975-91-5 C₂₇H₂₂N₈O₇ 

Relevant academic research and scientific papers

A fully complementary, high-affinity receptor for phosphate and sulfate based on an acyclic tris(urea) scaffold

A fully complementary tris(urea) receptor for phosphate and sulfate anions has been developed by mimicking the scaffold of terpyridine which shows very high affinities and selectivities toward the tetrahedral anions.

Investigation of active sites using solid state 27Al and 31P MAS NMR in ceramic amorphous aluminophosphate materials prepared from different potassium salts of phosphate for the synthesis of diphenyl urea derivatives

Ceramic amorphous aluminophosphate (CAmAlP) catalysts were prepared by precipitation method using different phosphate salts of potassium such as KH2PO4, K4P2O7 and K2HPO4 as well as H3PO4. The prepared materials were characterized by PXRD, FT-IR, XPS, SEM, BET Surface area, NH3-TPD, 27Al NMR and 31P NMR analytical methods. The catalytic activity of the materials was checked in the synthesis of diphenyl urea (DPU) from aniline and diethyl carbonate, under refluxing conditions. Further, the general application of the catalysts was tested using various substituted anilines. The recyclability of the catalysts was also studied. Uncertainties in percentage yields were calculated to check the reproducible surface properties. The P-XRD, BET Surface area and NH3-TPD results indicated that the materials were amorphous with mesoporous texture, surface areas and acidities in the range 200–260 m2/g and 0.4–0.7 mmol/g respectively. 27Al NMR studies revealed that Al is present in three different coordination states such as tetrahedral, pentagonal and octahedral. The relative percentages of these Al sites depends on the type of the potassium precursor phosphate salt used. Both tetrahedral and pentagonal Al sites in conjunction with each other represented catalytically active sites. An increase in the pentagonal sites contributed to additional increments to the catalytic activity of CAmAlP. The catalyst prepared from KH2PO4 was found to be the best and demonstrated 96% DPU yield.

Tris-ureas as transmembrane anion transporters

Nine tris-urea receptors (L1-L9) have been synthesised and shown to coordinate to a range of anionic guests both by 1H NMR titration techniques and single crystal X-ray structural analysis. The compounds have been shown to be capable of mediating the exchange of chloride and nitrate and also chloride and bicarbonate across POPC or POPC:cholesterol 7:3 vesicle bilayer membranes at low transporter loadings. An interesting dependency of anion transport on the nature of the cation is evidence to suggest that a M+/Cl- cotransport process may also contribute to the release of chloride from the vesicles.

Process for Preparing Disubstituted Urea and Carbamate Compounds from Amines, Carbon Dioxide, and Epoxides

The present disclosure relates to a method for preparing a disubstituted urea and carbamate compounds simultaneously through a one-pot reaction of an amine, carbon dioxide and an alkylene oxide compound in the presence of an ionic liquid-based complex catalyst system containing indium. In accordance with the present disclosure, a disubstituted urea and carbamate compounds can be prepared simultaneously at high yield. In addition, the ionic liquid-based catalyst containing indium according to the present disclosure is economical because it can be reused several times.

N.C.A [11C]CO2 as a safe substitute for phosgene in the carbonylation of primary amines

An efficient one-pot synthesis of [11C]ureas and [11C]isocyanates via dehydration of intermediately formed carbamate salts is described as a general alternative to their formation via [11C]phosgene. After optimization of the reaction parameters, in-target produced n.c.a. [11C]CO2 can be used for labelling in a one pot reaction within a very short reaction time of 10 minutes resulting in good radiochemical yields. The developed method has been applied to the 11C-carbonylation of aniline, benzyl- and phenethylamine and 1,2-diaminobenzene yielding the appropriate n.c.a. [11C]ureas in about 65, 85, 25 and 70% radiochemical yield (RCY), respectively. The presented reaction sequence can be handled easily and safely and lends itself to simple automation.