1504-15-0Relevant articles and documents
Acid mediated coupling of aliphatic amines and nitrosoarenes to indoles
Roy, Subhra Kanti,Purkait, Anisha,Aziz, Sk Md Tarik,Jana, Chandan K.
supporting information, p. 3167 - 3170 (2020/03/23)
Traditionally, amines react with nitrosoarenes to provide the corresponding imines or azo compounds. Herein, we report an acid mediated annulation reaction of aliphatic amines and nitrosoarenes to provide indole derivatives. The elusive direct annulation of aliphatic amines and nitrosoarenes via simultaneous C-C and C-N bond formation was achieved under metal free conditions. This conceptually novel method for indole synthesis does not require pre-functionalization steps for the new C-C and C-N bond formation. The method has been applied for an elegant synthesis of nor-neocryptolepine and neocryptolepine.
PDE4B inhibitors
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Page/Page column 57, (2008/06/13)
Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and strucural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.