1504-15-0

Basic information

• Product Name: 3-(3,4-dimethoxyphenyl)-1H-indole
• CAS NO: 1504-15-0
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.2958
• Mol File: 1504-15-0.mol

Chemical Properties

• Boiling Point: 435.79°C at 760 mmHg
• Flash Point: 156.9°C
• Density: 1.177g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: 3-(3,4-dimethoxyphenyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-dimethoxyphenyl)-1H-indole(1504-15-0)
• EPA Substance Registry System: 3-(3,4-dimethoxyphenyl)-1H-indole(1504-15-0)

Safety Data

• Hazardous Substances Data: 1504-15-0(Hazardous Substances Data)

Upstream product

• 93013-76-4 4-(3,4-dimethoxy-phenyl)-cinnoline 
• 4302-52-7 4-ethynylveratrole 
• 100-65-2 N-Phenylhydroxylamine 
• 65341-60-8 [2-(3,4-dimethoxyphenyl)ethyl]phenylamine 
• 586-96-9 Nitrosobenzene 
• 690666-78-5 1-amino-2-[1-(3,4-dimethoxyphenyl)ethenyl]benzene 

Relevant articles and documents

Acid mediated coupling of aliphatic amines and nitrosoarenes to indoles

Traditionally, amines react with nitrosoarenes to provide the corresponding imines or azo compounds. Herein, we report an acid mediated annulation reaction of aliphatic amines and nitrosoarenes to provide indole derivatives. The elusive direct annulation of aliphatic amines and nitrosoarenes via simultaneous C-C and C-N bond formation was achieved under metal free conditions. This conceptually novel method for indole synthesis does not require pre-functionalization steps for the new C-C and C-N bond formation. The method has been applied for an elegant synthesis of nor-neocryptolepine and neocryptolepine.

Direct synthesis of 3-arylindoles via annulation of aryl hydroxylamines with alkynes

3-Arylindoles are produced in moderate to excellent yields from the reaction between aryl hydroxylamines and alkynes catalyzed by 10 mol % iron(II) phthalocyanine [Fe(Pc)]. Terminal and internal alkynes afford 3-aryl substituted indoles exclusively. Elect

PDE4B inhibitors

Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and strucural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.