150403-96-6 Usage
Description
L-N5-(1-IMINOPROPYL) ORNITHINE (HYDROCHLORIDE) is a compound that functions as a competitive inhibitor of nitric oxide synthase (NOS). It is structurally similar to L-arginine, the natural substrate of NOS, and competes with it for binding to the enzyme's active site. L-N5-(1-IMINOPROPYL) ORNITHINE (HYDROCHLORIDE) is particularly effective as an inhibitor of neuronal NOS (nNOS), with a higher affinity (Ki = 3.0 μM) compared to endothelial NOS (eNOS, Ki = 10.0 μM) and inducible NOS (iNOS, Ki = 9.5 μM).
Uses
Used in Pharmaceutical Research:
L-N5-(1-IMINOPROPYL) ORNITHINE (HYDROCHLORIDE) is used as a research tool for studying the role of nitric oxide in various physiological and pathological processes. By inhibiting NOS, it helps researchers understand the effects of nitric oxide on cell signaling, immune response, and other functions.
Used in Neurological Applications:
In the field of neurology, L-N5-(1-IMINOPROPYL) ORNITHINE (HYDROCHLORIDE) is used as a selective inhibitor for nNOS. This application is crucial for investigating the specific roles of neuronal nitric oxide in brain function and neurodegenerative diseases, as well as for developing potential therapeutic strategies targeting nNOS.
Used in Cardiovascular Research:
L-N5-(1-IMINOPROPYL) ORNITHINE (HYDROCHLORIDE) is utilized as an inhibitor of eNOS in cardiovascular research. This application aids in the study of endothelial nitric oxide's role in vascular health, blood pressure regulation, and the prevention of atherosclerosis.
Used in Inflammatory Disease Studies:
In the context of inflammatory diseases, L-N5-(1-IMINOPROPYL) ORNITHINE (HYDROCHLORIDE) is used as an inhibitor of iNOS. This application is valuable for exploring the contribution of inducible nitric oxide to inflammation, pain, and tissue damage, as well as for the development of anti-inflammatory drugs.
Used in Drug Development:
L-N5-(1-IMINOPROPYL) ORNITHINE (HYDROCHLORIDE) serves as a lead compound in the development of new drugs targeting NOS enzymes. Its selective inhibition of nNOS, eNOS, and iNOS makes it a promising candidate for the creation of therapeutic agents for various conditions, including neurological disorders, cardiovascular diseases, and inflammatory conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 150403-96-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,0,4,0 and 3 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 150403-96:
(8*1)+(7*5)+(6*0)+(5*4)+(4*0)+(3*3)+(2*9)+(1*6)=96
96 % 10 = 6
So 150403-96-6 is a valid CAS Registry Number.
