150417-17-7

Basic information

• Product Name: (S)-3-AMINOMETHYL-2-BOC-3,4-DIHYDRO-1H-ISOQUINOLINE
• Synonyms: (S)-3-AMINOMETHYL-2-BOC-3,4-DIHYDRO-1H-ISOQUINOLINE;2(1H)-Isoquinolinecarboxylic acid, 3-(aminomethyl)-3,4-dihydro-, 1,1-dimethylethyl ester, (3S)-
• CAS NO: 150417-17-7
• Molecular Formula: C₁₅H₂₂N₂O₂
• Molecular Weight: 262.35
• Mol File: 150417-17-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-3-AMINOMETHYL-2-BOC-3,4-DIHYDRO-1H-ISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-AMINOMETHYL-2-BOC-3,4-DIHYDRO-1H-ISOQUINOLINE(150417-17-7)
• EPA Substance Registry System: (S)-3-AMINOMETHYL-2-BOC-3,4-DIHYDRO-1H-ISOQUINOLINE(150417-17-7)

Safety Data

• Hazardous Substances Data: 150417-17-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-3-AMINOMETHYL-2-BOC-3,4-DIHYDRO-1H-ISOQUINOLINE is used as a key intermediate in the synthesis of various pharmaceutical compounds due to its unique structure and reactivity. Its presence in the compound allows for the development of drugs with potential antiviral, antibacterial, antifungal, and anticancer properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (S)-3-AMINOMETHYL-2-BOC-3,4-DIHYDRO-1H-ISOQUINOLINE serves as a valuable building block for the creation of new drug molecules. Its versatility in organic synthesis and the presence of the BOC protecting group make it an ideal candidate for the development of innovative pharmaceutical agents.
Used in Drug Development:
(S)-3-AMINOMETHYL-2-BOC-3,4-DIHYDRO-1H-ISOQUINOLINE is utilized in drug development for its potential to contribute to the creation of novel therapeutic agents. Its diverse biological activities and compatibility with various synthetic pathways make it a promising candidate for the advancement of new treatments and medications.

Upstream product

• 183958-71-6 tert-butyl (3S)-3-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 115962-35-1 (3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid 
• 357339-32-3 Boc-L-Tic-CH₂N₃ 

Downstream Products

• 568587-85-9 3-[(3-phenyl-ureido)-methyl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 1042689-72-4 t-butyl (3S)-3-[(benzoylamino)methyl]-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 568587-94-0 2-[({3-[(3-phenyl-ureido)-methyl]-3,4-dihydro-1H-isoquinoline-2-carbothioyl}-amino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

NOVEL DIPEPTIDYL PEPTIDASE-IV INHIBITORS

The present invention relates to novel compounds exhibiting excellent inhibitory activity versus Dipeptidyl Peptidase-IV (DPP-IV), methods of preparing the same and pharmaceutical compositions containing the same as an active agent.

Dpp-IV Inhibitors

The invention relates to compounds of formula (I) wherein R1-9, Z, n, X, A, and Rb have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the pre

DPP-IV inhibitors

The invention relates to compounds of formula (I) wherein Z, R1-8, n, A1, X1 and X2 have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also

1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus

The invention relates to compounds of formula (I) wherein R1-9, Z, n, X, A, and Rb have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereof as medicament for the treatment of type 2 diabetes mellitus, obesity and lipid disorders.

New scaffolds in the development of Mu opioid-receptor ligands

A new class of μ selective receptor antagonists has been developed using a combinatorial approach based on previously reported Dmt-Tic dipeptide ligands. Modified tetrahydroisoquinoline (Tiq) residues were reacted with different electrophiles in order to