150450-96-7

Basic information

• Product Name: N-benzyl-2,6-dichloroquinazolin-4-amine
• Synonyms: N-benzyl-2,6-dichloroquinazolin-4-amine
• CAS NO: 150450-96-7
• Molecular Weight: 304.178
• Mol File: 150450-96-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: N-benzyl-2,6-dichloroquinazolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2,6-dichloroquinazolin-4-amine(150450-96-7)
• EPA Substance Registry System: N-benzyl-2,6-dichloroquinazolin-4-amine(150450-96-7)

Safety Data

• Hazardous Substances Data: 150450-96-7(Hazardous Substances Data)

Upstream product

• 20028-68-6 2,4,6-trichloroquinazoline 
• 100-46-9 benzylamine 

Downstream Products

• 1080622-93-0 VUF 10329 

Relevant articles and documents

Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities

Moderate cyclic GMP phosphodiesterase (cGMP-PDE, PDE V) inhibitor 2- phenyl-4-anilino-quinazoline (1) was identified utilizing MultiCASE assisted drug design (MCADD) technology. Modification of compound 1 was conducted at the 2-, 4-, and 6-positions of the quinazoline ring for enhancement of cGMP- PDE inhibitory activity. The 6-substituted 2-(imidazol-1-yl)-quinazolines are 1000 times more potent in in vitro PDE V enzyme assay than the well-known inhibitor zaprinast. The 6-substituted derivatives of 2-(3- pyridyl)quinazoline 84 and 2-(imidazol-1-yl)quinazoline 86 exhibited more than 1000-fold selectivity for PDE V over the other four PDE isozymes. In addition, cGMP-PDE inhibitors 64, 65, and 73 were found to have an additional property of thromboxane synthesis inhibitory activity.

USE OF COMPOUNDS FOR PREPARING ANTI-TUBERCULOSIS AGENTS

Compounds of a compound of compound of general formula (I) wherein X1, X2, A, R1R2, R3 and R4 are as defined herein; are useful as anti-mycobacterial agents, especially agents for the treatment of tuberculosis.

Method of treating a patient having a precancerous lesions with amide quinazoline derivatives

Derivatives of quinazoline are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.