150560-49-9Relevant academic research and scientific papers
Novel nonprostanoid prostacyclin (PGI2) mimetics with heterocyclic moiety
Nagao, Yuuki,Takahashi, Kanji,Torisu, Kazuhiko,Kondo, Kigen,Hamanaka, Nobuyuki
, p. 517 - 523 (2007/10/03)
Structural modification of [2-(2-benzhydryloxyiminopentyl)-1,2,3,4-tetrahydro-5-naphthyloxy]acetic acid (4), previously identified as a PGI2 agonist without a PG skeleton, was examined. Conversion of the oxime moiety in 4 to the pyrazole led to [2-(4-benzhydrylpylazoyl)methyl-1,2,3,4-tetrahydro-5-naphthyloxy]acetic acid (34) which strongly inhibited ADP-induced aggregation of human platelets in vitro.
Fused benzeneoxyacetic acid derivatives
-
, (2008/06/13)
A fused benzeneoxyacetic acid derivative of the formula (I): STR1 R1 is OH, alkoxy, (alkyl)amino, residue of an amino acid; A is phenyl, alkyl substituted by phenyl, residue of an imidazole, imidazole-2-yloxy(thio), 2-oxoimidazole, pyrazole, ox
