150575-95-4Relevant academic research and scientific papers
O-Demethylation of opioid derivatives with methane sulfonic acid/methionine: Application to the synthesis of naloxone and analogues
Andre,Dormoy,Heymes
, p. 2313 - 2327 (1992)
Naloxone 2 was obtained by demethylation of N-allylnoroxycodone 1 with methane sulfonic acid/methionine. This reagent is an excellent substitute for boron tribromide. It was used for the synthesis of analogous derivatives with variable results.
Novel nalmefene dimer as well as preparation method and application thereof
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Paragraph 0088-0090, (2021/10/13)
The invention relates to a novel nalmefene dimer compound with a structure as shown in a formula (I) or a salt thereof, and a preparation method and application of the compound, and the compound has a relatively strong inhibition effect on prostate cancer cell lines LNCaP and 22Rv1, and can be used for preparing drugs for resisting prostate cancer.
Wittig-reaction processes
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, (2008/06/13)
Disclosed are improved Wittig reaction processes wherein the Wittig reaction is conducted in an anisole containing solvent.
Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
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, (2008/06/13)
An improved Wittig reaction for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone from naloxone and naltrexone utilizing an alkoxide base in an ethereal solvent.
