150577-70-1

Basic information

• Product Name: (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexane
• Synonyms: (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexane
• CAS NO: 150577-70-1
• Molecular Weight: 292.422
• Mol File: 150577-70-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexane(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexane(150577-70-1)
• EPA Substance Registry System: (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexane(150577-70-1)

Safety Data

• Hazardous Substances Data: 150577-70-1(Hazardous Substances Data)

Downstream Products

• 150544-95-9 N--(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexan-2-amine 
• 135632-42-7 N--(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexan-2-amine 
• 129765-76-0 N-im-(2,4-dinitrophenyl)-L-histidyl>-(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexan-2-amine 
• 135632-48-3 [1-((S)-2-{(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethylcarbamoyl}-3-phenyl-propane-1-sulfonyl)-piperidin-4-yl]-carbamic acid tert-butyl ester 
• 135683-92-0 N--(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6(2-pyridyl)-hexane-2-amide acetate 
• 135650-90-7 [1-((R)-3-{(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethylcarbamoyl}-4-naphthalen-1-yl-butyryl)-piperidin-4-yl]-carbamic acid tert-butyl ester 
• 150545-03-2 Methyl-{2-[methyl-(morpholine-4-carbonyl)-amino]-ethyl}-carbamic acid (S)-1-{(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethylcarbamoyl}-2-phenyl-ethyl ester 
• 135632-32-5 4-tert-Butoxycarbonylamino-piperidine-1-carboxylic acid (S)-1-{(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethylcarbamoyl}-2-phenyl-ethyl ester 
• 135650-85-0 (2S,3R,4S)-N-piperidyl>carbonyl>propionyl>N^im-2-(2,4-dinitrophenyl)-L-histidinyl>-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexan-2-amine 
• 150545-00-9 (S)-2-Benzyl-N-{(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-3-(2-methyl-propane-2-sulfonyl)-propionamide 
• 150545-02-1 (R)-2-Benzyl-N-{(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-4-morpholin-4-yl-4-oxo-butyramide 
• 135650-75-8 (1-{(S)-2-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-3-phenyl-propane-1-sulfonyl}-piperidin-4-yl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Renin inhibitors containing a pyridyl amino diol derived C-terminus

Based on the concept of transition-state analogs, a series of nonpeptide renin inhibitors with the new (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy- 6-(2-pyridyl)hexane moiety at the C-terminal functionality were synthesized and evaluated for inhibition