150618-98-7

Upstream product

• 19867-89-1 2-(4-chlorophenyl)-1H-pyrrole 
• 1443036-49-4 1-phenyl-2-(phenyl-λ³-iodaneylidene)-2-((trifluoromethyl)sulfonyl)ethan-1-one 
• 421-83-0 trifluoromethane sulfonyl chloride 

Downstream Products

• 150619-05-9 2-(p-chlorophenyl)-3-nitro-5-[(trifluoromethyl)thio]pyrrole 
• 150619-06-0 5-(p-chlorophenyl)-3-nitro-2-[(trifluoromethyl)thio]pyrrole 
• 150618-99-8 3-bromo-2-(p-chlorophenyl)-5-[(trifluoromethyl)thio]pyrrole 

Relevant academic research and scientific papers

Copper-catalyzed regioselective trifluoromethylthiolation of pyrroles by trifluoromethanesulfonyl hypervalent iodonium ylide

The copper-catalyzed trifluoromethylthiolation of pyrroles with a trifluoromethanesulfonyl hypervalent iodonium ylide under mild conditions has been achieved. A broad set of pyrroles could be transformed to the corresponding products in moderate to excellent yields. The reaction mechanism is hypothesized.

Novel Use of CF3SO2Cl for the Metal-Free Electrophilic Trifluoromethylthiolation

The regioselective trifluoromethylthiolation of indole derivatives was achieved under reductive conditions with trifluoromethanesulfonyl chloride as the readily available source of electrophilic SCF3 and a phosphine as the reducing agent. It is a straightforward process free from any metal and also applicable for the trifluoromethylthiolation of other azaarenes, enamines, and enoxysilanes.