15067-20-6

Basic information

• Product Name: 3β-Azido-5α-cholestane
• Synonyms: 3β-Azido-5α-cholestane;(3R,5S,8R,9S,10S,13R,14S,17R)-3-azido-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthrene(WXG01425)
• CAS NO: 15067-20-6
• Molecular Weight: 0
• Mol File: 15067-20-6.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3β-Azido-5α-cholestane(CAS DataBase Reference)
• NIST Chemistry Reference: 3β-Azido-5α-cholestane(15067-20-6)
• EPA Substance Registry System: 3β-Azido-5α-cholestane(15067-20-6)

Safety Data

• Hazardous Substances Data: 15067-20-6(Hazardous Substances Data)

Upstream product

• 3381-51-9 (3S,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl methanesulfonate 
• 182243-57-8 Chloro-methanesulfonic acid (3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester 
• 80-97-7 Cholestanol 
• 3381-52-0 3β-(toluene-4-sulfonyloxy)-5α-cholestane 

Downstream Products

• 5457-79-4 3α-amino-5α-cholestane hydrochloride 
• 2206-20-4 3α-amino-5α-cholestane 

Relevant articles and documents

An efficient method for converting alcohols to azides with 2,4,4,6-tetrabromo-2,5-cyclohexadienone/PPh3/Zn(N3)2·Py

Treatment of the salt generated from 2,4,4,6-tetrabromo-2,5-cyclohexadienone and PPh3 in a mixed solvent of CH3CN/toluene with primary and secondary alcohols in the presence of Zn(N3)2·Py led to azides in excellent yields with inversion of configuration. Addition of hexamethylphosphorictriamide considerably accelerated the reaction.

Zinc Azide Mediated Mitsunobu Substitution. An Expedient Method for the One-Pot Azidation of Alcohols

In the presence of the diisopropyl azodicarboxylate/triphenylphosphine couple, alcohols react with zinc azide/bis-pyridine complex to give various azides via a Mitsunobu-type substitution.

METHODS OF ACTIVATING MICROGLIAL CELLS

The present disclosure provides methods of using compositions that inhibit SH2-containing inositol 5'-phosphatases (SHIPs) for activating microglial cells, as well as methods for using such compositions for treatment or ameliorating of neurodegenerative disorders in a subject.

DERIVATIVES OF STEROID BENZYLAMINES, HAVING AN ANTIPARASITIC ANTIBACTERIAL, ANTIMYCOTIC AND/OR ANTIVIRAL ACTION

The present invention relates to compounds derived from steroids of the general formula (I) wherein L represents a linker and R# represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis a