150694-32-9Relevant academic research and scientific papers
SYNTHESIS OF N-ALKYL-1,2,4-OXADIAZINONES AS ANGIOTENSIN-II (AT1) RECEPTOR ANTAGONISTS
Weller, Harold N.,Miller, Arthur V.,Dickinson, Kenneth E.,Hedberg, S. Anders,Delaney, Carol L.,et al.
, p. 1027 - 1038 (2007/10/02)
4-Alkyl-1,2,4-oxadiazinones were prepared by regiospecific alkylation of the corresponding 4H-oxadiazinones, which were synthesized by a trimethylaluminium mediated cyclization reaction.Alkylation was regiospecyfic and generally facile; in one example, however, an unusual fragmentation reaction occurred.A homochiral oxadiazineone was also prepared and alkylated under the described conditions. 4-Biphenylmethyl-1,2,4-oxadi-azinones were potent angiotensin-II receptor antagonists.
BIPHENYL OXADIAZINONE ANGIOTENSIN II INHIBITORS
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, (2008/06/13)
Angiotension II inhibition is exhibited by STR1 wherein: R. sup.1 and R 2 are each independently hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, thiophenalkyl, pyridylalkyl, or--R 8 CO. sub.2 R 9 ;R 3 is a single bond,--S--, or--O--;
